{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:00:14Z","timestamp":1785297614982,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Among the predisposing factors implicated in the immune response to airway bacterial infections, genetic variations of the bitter taste receptor TAS2R38, which is expressed in the cilia of the human sinonasal epithelial cells, seem to be associated with susceptibility to chronic rhinosinusitis (CRS) and in vitro biofilm formation. Polymorphisms in TAS2R38 generate two common haplotypes: the nonfunctional AVI (Alanine, Valine, Isoleucine) and the functional PAV (Proline, Alanine, Valine) alleles, with the latter protecting against gram\u2010negative sinonasal infections.<\/jats:p><jats:p>The aim of this study is to investigate for the first time the relevance of TAS2R38 genetic variants in the susceptibility to bacterial infections associated with in vivo biofilm formation in chronic rhinosinusitis with nasal polyps (CRSwNP) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective study on 100 adult patients undergoing functional endoscopic sinus surgery (FESS) for CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Propylthiouracile (PROP) testing and TAS2R38 genotyping were applied to characterize patients for receptor functionality. Sinonasal mucosa samples were processed for microbiological examination and biofilm detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nonfunctional genotype is more frequent among CRS patients than in the general population (25% vs. 18.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.034). Airway gram\u2010negative infections are primarily associated with the AVI haplotype (88.9% vs. 11.1% PAV\/PAV\u2010functional genotype, <jats:italic>P<\/jats:italic>\u2009=\u20090.023). Biofilm formation is prevalent in CRS patients with the AVI nontaster phenotype (62.5% vs. 33.3% PAV taster or supertaster phenotype, <jats:italic>P<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm an inverse correlation between TAS2R38 functionality and gram\u2010negative infections in Italian patients with CRSwNP. In addition, for the first time we demonstrated a relationship between in vivo microbial biofilm and TAS2R38 receptor variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 128:E339\u2013E345, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27175","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T19:26:42Z","timestamp":1521833202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["In Vivo Biofilm Formation, Gram\u2010Negative Infections and <scp>TAS<\/scp>2<scp>R<\/scp>38 Polymorphisms in <scp>CRS<\/scp>w <scp>NP<\/scp> Patients"],"prefix":"10.1002","volume":"128","author":[{"given":"Elena","family":"Cantone","sequence":"first","affiliation":[{"name":"Department of Neuroscience ENT 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Medicine and Medical Biotechnology, Section of Clinical Microbiology University of Naples \u201cFederico II\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head\u2013Neck Surgery Monaldi\u2010Ospedale dei Colli Naples Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Maffei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head\u2013Neck Surgery Monaldi\u2010Ospedale dei Colli Naples Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amata Amy","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, Section of Clinical Microbiology University of Naples \u201cFederico II\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo 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