{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:01:24Z","timestamp":1783652484609,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Polypoid edema of the middle turbinate is a marker of inhalant allergy. Extensive edematous changes may result in limited central nasal and sinus disease, which has been called central compartment atopic disease (CCAD). Radiologically, this is seen as soft tissue thickening in the central portion of the sinonasal cavity with or without paranasal sinus involvement. When the sinuses are involved, the soft tissue thickening spares the sinus roof or lateral wall (centrally limited). This centrally limited radiological pattern was assessed among chronic rhinosinusitis (CRS) patients and compared to allergy status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Diagnostic cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included consecutive CRS patients without prior sinus surgery. Computed tomography (CT) scans of the paranasal sinuses were blindly assessed and allergy status was confirmed by serum or skin testing. Individual sinus cavities were defined as either centrally limited or diffuse disease. The radiological pattern that may predict allergy was determined, and its diagnostic accuracy was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twelve patients diagnosed to have CRS, representing 224 sides, were assessed (age 46.31\u2009\u00b1\u200913.57 years, 38.39% female, 41.07% asthma, Lund\u2010Mackay CT score 15.88\u2009\u00b1\u20094.35, 56.25% atopic). The radiological pattern defined by centrally limited changes in all of the paranasal sinuses was associated with allergy status (73.53% vs. 53.16%, <jats:italic>P<\/jats:italic>\u2009=\u2009.03). This predicted atopy with 90.82% specificity, 73.53% positive predictive value, likelihood positive ratios of 2.16, and diagnostic odds ratio of 4.59.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A central radiological pattern of mucosal disease is associated with inhalant allergen sensitization. This group may represent a CCAD subgroup of patients with mainly allergic etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b <jats:italic>Laryngoscope<\/jats:italic>, 128:2015\u20132021, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27180","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T23:59:06Z","timestamp":1522454346000},"page":"2015-2021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-963X","authenticated-orcid":false,"given":"Aneeza W.","family":"Hamizan","sequence":"first","affiliation":[{"name":"Rhinology and Skull Base Research Group St. Vincent's Centre for Applied Medical Research, University of New South Wales Sydney Australia"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Loftus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St. Vincent's Centre for Applied Medical Research, University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-8684","authenticated-orcid":false,"given":"Jacqueline","family":"Ho","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St. Vincent's Centre for Applied Medical Research, University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Kalish","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Concord General Hospital, University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Sacks","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney Australia"},{"name":"Faculty of medicine and Health Sciences Macquarie University Sydney Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Concord General Hospital, University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"DelGaudio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St. Vincent's Centre for Applied Medical Research, University of New South Wales Sydney Australia"},{"name":"Faculty of medicine and Health Sciences Macquarie University Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21290"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21835"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817711887"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4443"},{"key":"e_1_2_6_6_1","first-page":"3","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_8_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","unstructured":"Australasian Society of Clinical Immunology and Allergy Limited.Pollen calendar\u2014guide to common allergenic pollen. 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