{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:19:11Z","timestamp":1787800751500,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Clinical Trial Registry","award":["KCT0001805"],"award-info":[{"award-number":["KCT0001805"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Avoidance of organs at risk has become possible with advances in image\u2010guided volumetric\u2010modulated arc therapy (VMAT) techniques. This study was designed to evaluate the safety and feasibility of stereotactic ablative radiotherapy (SABR) for early stage glottic cancer. This report presents the preliminary result of the first and second dose level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fraction size was increased from 3.5 gray (Gy) (total dose 59.5 Gy) to 9 Gy (total dose 45 Gy). Dose\u2010limiting toxicities were defined as grade 3 or higher treatment\u2010related toxicities. Voice outcome was assessed with electroglottography, and quality of life (QoL) was measured with the Head and Neck Cancer Inventory (HNCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients received 59.5 Gy at 3.5 Gy per fraction as the first dose level, and five patients received 55 Gy at 5 Gy per fraction as the second dose level. None of the patients developed grade 3+ toxicity throughout a median follow\u2010up of 17.5 months (range, 1.7\u201330.6 months). One patient in the second dose level recurred in the primary site at 4 months after radiotherapy (RT) and received total laryngectomy. The rest of participants were disease\u2010free at locoregional and distant sites. Jitter, shimmer, mean phonation time, and noise\u2010to\u2010harmony ratio did not change significantly at 6 months after RT. HNCI scores between pretreatment and posttreatment were not significantly different (<jats:italic>P<\/jats:italic>\u2009=\u20090.221).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed acceptable toxicity, voice outcome, and QoL in patients treated with hypofractionated VMAT of 3.5 Gy and 5 Gy per fraction. This phase I study is currently ongoing with a dose of 55 Gy in 11 fractions and 45 Gy in five fractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 2560\u20132565, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27226","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T08:49:33Z","timestamp":1526287773000},"page":"2560-2565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Study design and early result of a phase <scp>I<\/scp> study of <scp>SABR<\/scp> for early\u2010stage glottic cancer"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-8858","authenticated-orcid":false,"given":"Tosol","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Woo","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorie","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Gyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Medical Research Center Seoul National University Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institution Seoul National University College of Medicine Seoul Republic of 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