{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:15:32Z","timestamp":1784693732496,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate hearing performance and safety measures in a large group of totally implantable active middle ear implant (AMEI) wearers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case review of 172 ears (166 patients) with sensorineural hearing loss undergoing implantation of a totally implantable AMEI. Pure\u2010tone air and bone thresholds, pure\u2010tone average, speech reception threshold (SRT), and word recognition scores (WRS) at phonetically balanced maximum and at 50 dB (WRS50) were assessed at baseline unaided, with a hearing aid (baseline aided [BLA]), with the implant at activation, and for best implant postoperative measurement. Adverse events were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean length of follow\u2010up was 35.7 months. Compared to unaided, the implant provided significant gain at all frequencies through 6 kHz. Amount of gain was significantly better with the implant than BLA at 1,500 and 2,000\u2009Hz (<jats:italic>P<\/jats:italic>\u2009\u2264\u2009.001). Implant SRT was also significantly improved compared to BLA (29.9 dB vs. 38.5 dB, <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.001). At a 50\u2010dB presentation level, WRS was significantly better with the implant than BLA (65.6% vs. 45.5%, <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.001). Bone conduction thresholds were not affected by the implant. The most common adverse event was taste disturbance, which occurred in 39.1%. In subjects with preimplant tinnitus, 56.1% experienced resolution of their tinnitus. Revision surgery was required in 15.7%, and 4% were ultimately explanted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The implant provided significant hearing benefit compared to unaided and to the subjects' own hearing aids in most test categories, with minimal adverse events. Many subjects experienced complete resolution of their tinnitus after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 128:2872\u20132878, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27246","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T11:29:11Z","timestamp":1536406151000},"page":"2872-2878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Totally implantable active middle ear implant: Hearing and safety results in a large series"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-3033","authenticated-orcid":false,"given":"Jack A.","family":"Shohet","sequence":"first","affiliation":[{"name":"Shohet Ear Associates Newport Beach California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna M.","family":"Gende","sequence":"additional","affiliation":[{"name":"Shohet Ear Associates Newport Beach California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl S.","family":"Tanita","sequence":"additional","affiliation":[{"name":"Shohet Ear Associates Newport Beach California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"59","article-title":"The Esteem system: a totally implantable hearing device","volume":"69","author":"Maurer J","year":"2010","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181cabd42"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811401709"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182382bc8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/MAO.0000000000000341","article-title":"Middle ear implants for rehabilitation of sensorineural hearing loss: a systematic review of FDA approved devices","volume":"35","author":"Kahue CN","year":"2014","journal-title":"Otol Neurotol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1097\/MAO.0b013e3181db716c","article-title":"Systematic review of middle ear implants: do they improve hearing as much as conventional hearing aids?","volume":"31","author":"Tysome JR","year":"2010","journal-title":"Otol Neurotol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31829ce7d2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110636"},{"key":"e_1_2_6_10_1","first-page":"233","volume-title":"Otology and Neurotology","author":"Glasscock ME","year":"2013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2014.08.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26602"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.16067"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.536994"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1258733"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000943"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.868602"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23316"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4124-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4361-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.834459"},{"key":"e_1_2_6_23_1","first-page":"14","article-title":"Cost\u2010effectiveness of implantable middle ear hearing devices","volume":"69","author":"Snik A","year":"2010","journal-title":"Adv Otorhinolaryngol"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:41:32Z","timestamp":1694731292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,8]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/lary.27246"],"URL":"https:\/\/doi.org\/10.1002\/lary.27246","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,8]]},"assertion":[{"value":"2018-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}