{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:31:00Z","timestamp":1747150260392,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Head and neck cancers account for a significant proportion of reported malignancies in the United States; however, multiple concurrent primary malignancies from different sites are rare. We describe the case of a 44\u2010year\u2010old man simultaneously diagnosed with three independent head and neck malignancies (adenocarcinoma in minor salivary gland, papillary thyroid carcinoma, and acinic cell carcinoma) in the setting of Lynch syndrome. To our knowledge, this is the first case of multiple head and neck malignancies arising simultaneously from Lynch syndrome. This case highlights the need for diligent workup in patients with hereditary conditions that predispose to malignancies. <jats:italic>Laryngoscope<\/jats:italic>, 128:2759\u20132761, 2018<\/jats:p>","DOI":"10.1002\/lary.27259","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T12:54:40Z","timestamp":1539694480000},"page":"2759-2761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5299","authenticated-orcid":false,"given":"Allen L.","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts U.S.A"},{"name":"Harvard Medical School  Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts U.S.A"},{"name":"Department of Pathology Massachusetts General Hospital  Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-5672","authenticated-orcid":false,"given":"Mark A.","family":"Varvares","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts U.S.A"},{"name":"Harvard Medical School  Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500802129431"},{"key":"e_1_2_5_3_1","first-page":"80","article-title":"Multiple cancers of the head and neck","volume":"8","author":"Heroiu Cataloiu AD","year":"2013","journal-title":"Maedica (Buchar)"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt029"},{"key":"e_1_2_5_5_1","first-page":"3282","article-title":"Smoking and drinking in relation to oral and pharyngeal cancer","volume":"48","author":"Blot WJ","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22177"},{"key":"e_1_2_5_7_1","first-page":"g2","article-title":"Evidence of Epstein\u2010Barr virus association with head and neck cancers: a review","volume":"82","author":"Prabhu SR","year":"2016","journal-title":"JCan Dent Assoc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9464-6_5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30927-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880901)62:5<1007::AID-CNCR2820620528>3.0.CO;2-X"},{"key":"e_1_2_5_11_1","first-page":"1727","article-title":"A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications","volume":"63","author":"Braakhuis BJ","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_12_1","first-page":"2484","article-title":"Multiple head and neck tumors: evidence for a common clonal origin","volume":"56","author":"Bedi GC","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_5_13_1","first-page":"270","article-title":"Multiple primary tumors. 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