{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:49:45Z","timestamp":1773272985635,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health National Center for Advancing Translational Science Clinical and Translational Science","award":["UL1 TR001085"],"award-info":[{"award-number":["UL1 TR001085"]}]},{"name":"National Institutes of Health National Center for Advancing Translational Science Clinical and Translational Science Award"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the correlation of aging and upper airway collapse characteristics observed by drug\u2010induced sleep endoscopy (DISE), and report the observed differences on obstructive sleep apnea (OSA) subjects, older and younger than 60 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed the data of 200 OSA patients who underwent DISE between January 1, 2013 and June 30, 2017. The variables sex, body mass index (BMI), Epworth Sleepiness Scale score, tonsil size, modified Mallampati (MM) classification, apnea\u2010hypopnea index (AHI), oxygen desaturation index (ODI), lowest oxygen saturation, and VOTE (velum, oropharynx, tongue base, epiglottis) classification were compared between two groups:\u2009&lt;60 and \u226560 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older age had significant correlation with higher AHI, ODI, lower O<jats:sub>2<\/jats:sub> nadir, multisite obstruction, combined upper (palatopharyngeal)\u2009+\u2009lower (hypopharyngeal) level obstructions, and complete anterior\u2010posterior (AP) velum collapse pattern. Lateral oropharyngeal wall collapse was significantly lower in the older group. Findings remained statistically significant when adjusted for sex, BMI, tonsil size, and MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aging was an independent factor that directly correlated with increased AHI and hypoxemia, multisites, combined levels of obstruction, and complete AP velum collapse pattern. Being older than 60 years had higher of complete AP velum collapse and lower incidence of lateral oropharyngeal wall collapse, regardless of OSA severity and tonsil size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 2644\u20132650, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27265","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T18:46:36Z","timestamp":1536432396000},"page":"2644-2650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of aging on drug\u2010induced sleep endoscopy findings"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-7522","authenticated-orcid":false,"given":"Chen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology First Affiliated Hospital of China Medical University Shenyang 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