{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:44:14Z","timestamp":1779356654468,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03DC011145"],"award-info":[{"award-number":["R03DC011145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21DC013363"],"award-info":[{"award-number":["R21DC013363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective was to investigate the left\u2013right vocal fold symmetry in rheological and histological properties using a rabbit model. The other objective was to develop statistical models for the comparison of rheological properties between paired vocal folds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Viscoelastic shear properties of six pairs of vocal fold lamina propria specimens were measured over a frequency range of 1 to 250\u2009Hz by a linear, controlled\u2010strain, simple\u2010shear rheometer. The rheological data of the left and right vocal folds was statistically compared using the mixed\u2010effects model approach. Six additional rabbit larynges were histologically analyzed for left\u2013right symmetry in distribution patterns and relative densities of major extracellular matrix constituents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in elastic shear modulus (<jats:italic>P<\/jats:italic>\u2009=\u20090.1069) and dynamic viscosity (<jats:italic>P<\/jats:italic>\u2009=\u20090.944) of the lamina propria between the two vocal folds of the same larynx. Left\u2013right vocal fold symmetry in densities and distribution patterns of the key molecular constituents was also demonstrated in histological results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By showing that the left and right vocal folds were rheologically and histologically symmetrical in rabbit, this study validated an underlying assumption made in many previous reports. Statistical models for the analysis of hierarchically correlated left\u2013right vocal fold rheological data were also presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:E359\u2013E364, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27271","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T03:32:16Z","timestamp":1533958336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An investigation of left\u2013right vocal fold symmetry in rheological and histological properties"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-7608","authenticated-orcid":false,"given":"Chet C.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Texas Southwestern Medical Center Dallas Texas U.S.A"},{"name":"Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center Dallas Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Gao","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center Dallas Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2003.06.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611501009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21087"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00078-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.10.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2008\/07-0059)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2006.08.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.12.016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0133-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.427947"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.08.030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2946715"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.08.006"},{"key":"e_1_2_6_15_1","first-page":"324","volume-title":"Simple Linear Regression. In: Biostatistical Analysis","author":"Zar JH","year":"1998"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812446913"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1977.10480998"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500311"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(96)90155-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.04.006"},{"key":"e_1_2_6_23_1","first-page":"1335","article-title":"Controlled release of hepatocyte growth factor from a bovine acellular scaffold for vocal fold reconstruction","volume":"93","author":"Xu CC","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.12.019"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32279"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22143"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.96"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200401000-00025"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26883"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24707"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200111"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283407d87"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-011212-140636"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.3458839"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900115"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700508"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00007"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459980112400602"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400902"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224548.68499.35"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181379c7c"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.3201"},{"key":"e_1_2_6_44_1","first-page":"3","volume-title":"Vocal Fold Physiology: Contemporary Research and Clinical Issues","author":"Kurita S","year":"1983"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T17:45:13Z","timestamp":1694886313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/lary.27271"],"URL":"https:\/\/doi.org\/10.1002\/lary.27271","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,10]]},"assertion":[{"value":"2018-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}