{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:33:44Z","timestamp":1763037224847,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Voice Health Institute"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Wound healing after transoral angiolytic laser surgery for early glottic carcinoma was analyzed to identify factors influencing healing and clinical significance of persistent granulation tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 100 consecutive patients undergoing endoscopic angiolytic laser surgery for T1 and T2 glottic carcinoma was performed. Patients with prior radiation or incomplete data were excluded. Postoperative endoscopic images were analyzed for time to healing, size and location of wound, and presence of granulation tissue. Three blinded, independent raters graded wound appearance and presence of granulation tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine patients healed without need for intervention at a median of 3.5 months. Two patients had office\u2010based ablation of granulation without biopsy and healed. The remaining 19 patients had biopsy for granulation tissue. Wounds that underwent biopsy at &gt;3 months were more likely to contain carcinoma (5\/6 patients, 83%) than wounds that were biopsied &lt;3 months (2\/13 patients, 15%) (<jats:italic>P<\/jats:italic>\u2009=\u2009.004). Presence of granulation significantly correlated with resection involving anterior commissure (<jats:italic>P<\/jats:italic>\u2009=\u2009.01),\u2009&gt;\u200975%vocal fold length (<jats:italic>P<\/jats:italic>\u2009=\u2009.006), and depth into muscle (<jats:italic>P<\/jats:italic>\u2009=\u2009.001). Delayed healing (&gt;3 months) correlated with T2b tumors (<jats:italic>P<\/jats:italic>\u2009=\u2009.02), depth into ligament (<jats:italic>P<\/jats:italic>\u2009=\u2009.002) and anterior commissure involvement (<jats:italic>P<\/jats:italic>\u2009=\u2009.04). T1a carcinomas more commonly healed in &lt;3 months (<jats:italic>P<\/jats:italic>\u2009=\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many vocal fold wounds heal completely within 3.5 months after angiolytic laser surgery for early glottic carcinoma. Larger and deeper wounds are more likely to heal with granulation tissue. Granulation can resolve without surgical intervention; however, granulation present\u2009&gt;\u20093 months warrants biopsy due to increased risk of malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 129:435\u2013440, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27283","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T16:59:01Z","timestamp":1536425941000},"page":"435-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Wound healing after transoral angiolytic laser surgery for early glottic carcinoma"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7680-4713","authenticated-orcid":false,"given":"Lauren F.","family":"Tracy","sequence":"first","affiliation":[{"name":"Department of Surgery Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffiny A.","family":"Hron","sequence":"additional","affiliation":[{"name":"Department of Surgery Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarrad H.","family":"Van Stan","sequence":"additional","affiliation":[{"name":"Department of Surgery Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital Boston Massachusetts U.S.A"},{"name":"Department of Communication Sciences and Disorders Massachusetts General Hospital Institute of Health Professions Charlestown Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Surgery Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414538936"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200302"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21811"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700701"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316447303300309"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"A comparison of consensus, consistency, and measurement approaches to estimating interrater reliability","volume":"9","author":"Stemler 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