{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:12:48Z","timestamp":1778314368899,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T00:00:00Z","timestamp":1546128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Health Technology R&D Project"},{"name":"Ministry of Health & Welfare","award":["HI15C1512"],"award-info":[{"award-number":["HI15C1512"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the increase in the incidence of depression in patients with obstructive sleep apnea (OSA) and its preventability by uvulopalatopharyngoplasty (UPPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, data from the Korea National Health Insurance Corporation were analyzed. A total of 160,840 participants (age\u2009\u2265\u200920 years) who were newly diagnosed with OSA between 2007 and 2014 were included. The participants were classified into a group that underwent UPPP (UPPP group, n\u2009=\u200919,773) and a group that did not undergo surgical treatment (no surgery group, n\u2009=\u2009141,067). Propensity score matching by age and sex was used to select the control group of 804,200 subjects. The mean follow\u2010up duration was 4.6\u2009\u00b1\u20092.3 years. The primary endpoint was newly diagnosed depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of depression was higher in patients with OSA than in controls (hazard ratio [HR]: 1.678, 95% confidence interval [CI]: 1.650\u20131.706). The UPPP group was still at a higher risk of depression than was the control group (HR: 1.535, 95% CI: 1.463\u20131.610), but the HR was statistically lower than that in the no surgery group (HR: 1.694, 95% CI: 1.665\u20131.724).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA increases the incidence of depression, which may be prevented to some extent by UPPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b <jats:italic>Laryngoscope<\/jats:italic>, 129:1005\u20131009, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27294","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:57:45Z","timestamp":1546297065000},"page":"1005-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Uvulopalatopharyngoplasty reduces the incidence of depression caused by obstructive sleep apnea"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-7428","authenticated-orcid":false,"given":"Jae Hoon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Konkuk University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery UCLA School of Medicine  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Biomedicine &amp; Health Sciences Catholic University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Guro Hospital, Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-114MG"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199511000-00009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000280"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3928\/0279-3695-19991001-15","article-title":"Identifying depression as a symptom of sleep apnea","volume":"37","author":"Yantis MA","year":"1999","journal-title":"JPsychosoc Nurs Ment Health Serv"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0035"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.04.001"},{"key":"e_1_2_6_8_1","first-page":"17","article-title":"Obstructive sleep apnea and depression: a review","volume":"8","author":"Ejaz SM","year":"2011","journal-title":"Innov Clin Neurosci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.07.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24729"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816661481"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.2.156"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12655"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.12.019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.10.012"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370905401007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.11.1861"},{"key":"e_1_2_6_18_1","first-page":"46","article-title":"Obstructive sleep apnea syndrome and depression","volume":"84","author":"McFarlane JR","year":"1988","journal-title":"Tex Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0522-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.861"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.05.014"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00051504"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0770-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.13078\/jksrs.04015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7599\/hmr.2013.33.4.239"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.27294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:09:34Z","timestamp":1694398174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,30]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/lary.27294"],"URL":"https:\/\/doi.org\/10.1002\/lary.27294","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,30]]},"assertion":[{"value":"2018-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}