{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:42:24Z","timestamp":1784641344993,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Icahn School of Medicine Institutional Review Board (IRB)"},{"name":"Institutional funding Icahn School of Medicine at Mount Sinai."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Human papillomavirus (HPV) has been identified as a risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and a cause of the recent dramatic rise in the incidence of this disease. HPV\u2010positive OPSCC typically affects a younger population and has no validated screening test. This study aims to outline the common presenting signs of HPV\u2010positive OPSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective single\u2010institution review on 370 patients who were treated at the Icahn School of Medicine at Mount Sinai, New York City, between April 2007 and November 2015 for OPSCC. We included patients with newly diagnosed OPSCC and sufficient history and physical data in the final analysis. Univariate analysis was used to compare HPV\u2010positive and HPV\u2010negative cohorts for demographics, tumor location, tumor staging, initial presentation and symptoms, and physical exam findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seven patients met the inclusion criteria. The most common initial symptoms for OPSCC were neck mass (51.7%) and sore throat (13.0%). The HPV\u2010positive cohort was more likely to present with a chief complaint of neck mass compared to the HPV\u2010negative cohort (56.1% vs. 22.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0015). A positive neck exam was associated with HPV\u2010positive status (73.9% vs. 40.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV\u2010positive OPSCC is an incipient epidemic, poised to surpass cervical cancer as the most common HPV\u2010related cancer by 2020. Initial presenting signs may often be mistaken for benign processes. This study provides physicians with a better understanding of initial presentation of patients with HPV\u2010positive OPSCC, leading to earlier diagnosis and improved outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 129:877\u2013882, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27296","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T08:44:34Z","timestamp":1536396274000},"page":"877-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Initial presentation of human papillomavirus\u2010related head and neck cancer: A retrospective review"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-9593","authenticated-orcid":false,"given":"Mian B.","family":"Khalid","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York New 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