{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:34:14Z","timestamp":1791909254993,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>This multicenter study aimed to 1) evaluate early postoperative vocal fold function in relation to intraoperative amplitude recovery, and 2) determine optimal absolute and relative thresholds of intraoperative amplitude recovery heralding normal early postoperative vocal fold function, both after segmental type 1 and after global type 2 loss of signal (LOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective outcome study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study, encompassing nine surgical centers from four countries, correlated intraoperative amplitude recovery with early postoperative vocal fold function using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Included in this study were 68 patients, 48 women and 20 men, who sustained transient recurrent laryngeal nerve injury during thyroid surgery under continuous intraoperative nerve monitoring. Early transient vocal fold palsy was seen in 18 (64%) of 28 patients with ipsilateral segmental LOS type 1, and in 10 (25%) of 40 patients with ipsilateral global LOS type 2. On receiver operating characteristic analysis, relative amplitude thresholds were superior to absolute amplitude thresholds in predicting vocal fold function after LOS type 2 (area under the curve [AUC]: 0.83 vs. 0.65;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.01 vs.\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.15; Youden index 44% and 253\u2009\u00b5V) and LOS type 1 (AUC: 0.96 vs. 0.97;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001 each; Youden index 49% and 455\u2009\u00b5V). Amplitude recovery \u226550% of baseline after LOS always indicated intact vocal fold function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When the nerve amplitude recovers \u226550% of baseline after segmental LOS type 1 or global LOS type 2, it is appropriate to extend completion thyroidectomy to the other side during the same session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2b\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 129:525\u2013531, 2019\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.27327","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T08:45:37Z","timestamp":1537778737000},"page":"525-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Prediction of Postoperative Vocal Fold Function After Intraoperative Recovery of Loss of Signal"],"prefix":"10.1002","volume":"129","author":[{"given":"Rick","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Visceral, Vascular, and Endocrine Surgery University Hospital of Martin Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Randolph","sequence":"additional","affiliation":[{"name":"Division of Thyroid and Parathyroid Surgery Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-6087","authenticated-orcid":false,"given":"Gianlorenzo","family":"Dionigi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood \u201cG. Barresi\u201d University Hospital \u201cG. Martino,\u201d University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Barczynski","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Third Chair of General Surgery Jagiellonian University Medical College, Faculty of Medicine Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Yu","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-5348","authenticated-orcid":false,"given":"Che\u2010Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Musholt","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Section, Clinic of General, Visceral and Transplantation Surgery University Medical Center Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-1615","authenticated-orcid":false,"given":"Mehmet","family":"Uludag","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sisli Hamidiye Etfal Medical Practice and Research Center University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zer","family":"Makay","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atakan","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of General Surgery Trakya University Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Teks\u00f6z","sequence":"additional","affiliation":[{"name":"Department of General Surgery Cerrahpasa Medical Faculty Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Catholic Hospital Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Sekulla","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular, and Endocrine Surgery University Hospital of Martin Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular, and Endocrine Surgery University Hospital of Martin Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-079X","authenticated-orcid":false,"given":"Andreas","family":"Machens","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular, and Endocrine Surgery University Hospital of Martin Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Dralle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Transplantation Surgery, Section of Endocrine Surgery University of Duisburg\u2010Essen Essen 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