{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:34:00Z","timestamp":1787625240180,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Memorial Hospital, Taiwan","award":["CORPG3G0171"],"award-info":[{"award-number":["CORPG3G0171"]}]},{"name":"Chang Gung Memorial Hospital, Taiwan","award":["CIRPG3B0013"],"award-info":[{"award-number":["CIRPG3B0013"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The role of tumor\u2010associated tissue eosinophilia (TATE) in oral cavity cancer remains quite controversial. This study investigated the potential role of TATE in tongue squamous cell carcinoma (TSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively enrolled 259 consecutive TSCC patients who underwent surgery between July 2004 and December 2015. Histopathological examinations for TATE in TSCC tumors were reviewed, and the association of TATE with different clinicopathological factors was evaluated. A nomogram was generated based on several major clinicopathological factors and TATE to improve the accuracy of prognostic prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher levels of TATE were significantly associated with male sex, alcohol consumption, cigarette smoking, higher pT classification, advanced disease stage, and tumor depth (<jats:italic>P<\/jats:italic>\u2009=\u2009.006, .003, .024, .041, .013 and .006, respectively). Our results indicated that extranodal extension, cell differentiation, and TATE were independent predictors of overall survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, .004, and .032, respectively) and disease\u2010free survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, .012, and .013, respectively). TATE levels significantly correlated with circulating eosinophils (<jats:italic>r<\/jats:italic>\u2009=\u20090.139, <jats:italic>P<\/jats:italic>\u2009=\u2009.040), and the c\u2010index of our nomogram foroverall survival was 0.786, which demonstrates better accuracy in prognosis prediction than the TNM stage only (c\u2010index\u2009=\u20090.738).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher levels of TATE were associated with several clinicopathological factors and poorer survival rates, and a nomogram incorporating TATE levels may strengthen the prediction accuracy of prognosis in TSCC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 129:1123\u20131129, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27413","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T04:04:31Z","timestamp":1533960271000},"page":"1123-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical Implications of Tumor\u2010Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"129","author":[{"given":"Dante","family":"De Paz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Head and Neck Surgery  San Pedro University  Chimbote Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-9578","authenticated-orcid":false,"given":"Kai\u2010Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Medicine  Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-3834","authenticated-orcid":false,"given":"Huang\u2010Kai","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine  Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Wei\u2010Kai","family":"Lao","sequence":"additional","affiliation":[{"name":"College of Medicine  Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Liang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine  Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20099"},{"key":"e_1_2_6_3_1","unstructured":"Health Promotion Administration Ministry of Health and Welfare.Cancer registry annual report 2013. 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