{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:46:17Z","timestamp":1789562777711,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>We discuss a unique case of sudden sensorineural hearing loss after Cialis (tadalafil) use, a phosphodiesterase 5 (PDE5) inhibitor, and the implication of ipsilateral cochlear hydrops seen on magnetic resonance imaging (MRI). We report a case of a 53\u2010year\u2010old male with unilateral low\u2010frequency sudden sensorineural hearing loss (SSNHL) after ingestion of tadalafil. The SSNHL occurred 1 day after ingestion and was associated with aural fullness and tinnitus. There were no symptoms of vertigo. He received oral prednisone immediately after the onset of hearing loss without improvement. Delayed intravenous contrast\u2010enhanced three\u2010dimensional Fluid\u2010attenuated inversion recovery MRI revealed ipsilateral dilation of the cochlear duct without any hydronic change in the vestibular system. Acetazolamide therapy was initiated, and his symptoms improved. A posttreatment audiogram revealed an increase in threshold of 15 dB. To the best of our knowledge, this is the first case of cochlear hydrops visualized on imaging after a PDE5 inhibitor induced SSNHL. Tadalafil and other PDE5 inhibitors have a known association with SSNHL. Despite several proposed mechanisms, there is inconclusive evidence of a causal relationship. Our presented case suggests that cochlear hydrops may be one possible mechanism of PDE5 inhibitor\u2013associated SSNHL. MRI should be considered in the evaluation of such patients who do not respond to oral steroids as initial treatment. <jats:italic>Laryngoscope<\/jats:italic>, 2615\u20132618, 2018<\/jats:p>","DOI":"10.1002\/lary.27428","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T18:54:24Z","timestamp":1536778464000},"page":"2615-2618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sudden hearing loss after cialis (tadalafil) use: A unique case of cochlear hydrops"],"prefix":"10.1002","volume":"128","author":[{"given":"Jacob L.","family":"Wester","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stellios","family":"Karnezis","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences University of California Los Angeles  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005276847"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106005512"},{"key":"e_1_2_5_5_1","unstructured":"FDA announces revisions to labels for Cialis Levitra and Viagra: potential risk of sudden hearing loss with ED drugs to be displayed more prominently. 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