{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:25:46Z","timestamp":1773458746407,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Salivary squamous cell carcinomas (SCCs) represent a unique disease entity because many are thought to represent metastases from primary cutaneous malignancies. Nevertheless, they represent a significant proportion of parotid gland cancers and have a notably poor prognosis. Recently, there has been controversy regarding the utility of adjuvant chemotherapy in the treatment of these malignancies, with most studies concluding that there is no survival benefit. We aim to determine the outcomes associated with the use of adjuvant radiotherapy and chemoradiotherapy in the treatment of early\u2010 and late\u2010stage salivary SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of 2,285 of surgically resected adult salivary SCC diagnosed from 2004 to 2014 in the National Cancer Database was conducted. Patients were divided into early\u2010 (I\/II) and late\u2010stage (III\/IV) groups. Demographic, facility, tumor, and survival variables were included in the analyses. Multivariate Cox survival regressions, propensity\u2010score matched analyses, and univariate Kaplan\u2010Meier analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of adjuvant chemoradiotherapy for late\u2010stage patients was associated with improved survival compared to the use of adjuvant radiotherapy alone (hazard ratio [HR] 0.774, <jats:italic>P<\/jats:italic>\u2009=\u20090.026). Five\u2010year survival for late\u2010stage patients treated with surgery alone, surgery with adjuvant radiotherapy, and surgery with adjuvant chemoradiotherapy was 31.1% (standard error [SE]: 2.5), 45.6% (SE: 2.2), and 58.9% (SE: 3.4). Use of adjuvant therapy (either chemoradiotherapy or radiotherapy alone) was associated with improved survival for early\u2010stage patients (HR 0.746, <jats:italic>P<\/jats:italic>\u2009=\u20090.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of chemotherapy to the adjuvant therapy of late\u2010stage patients with salivary SCC may result in improved long\u2010term survival. Expanded use of adjuvant therapy for early\u2010stage disease may also improve patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 129:883\u2013889, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27444","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T16:57:26Z","timestamp":1535475446000},"page":"883-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adjuvant Chemotherapy Is Associated With Improved Survival for Late\u2010Stage Salivary Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"129","author":[{"given":"Shayan","family":"Cheraghlou","sequence":"first","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Schettino","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl K.","family":"Zogg","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Otremba","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarti","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Medicine  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saral","family":"Mehra","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendell G.","family":"Yarbrough","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"},{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin L.","family":"Judson","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery  New Haven Connecticut U.S.A"},{"name":"Yale Cancer Center  New Haven Connecticut U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"662","volume-title":"Cancer: Principles and Practice of Oncology","author":"Mendenhall WM","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90142-Z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655402\/000028047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0768-y"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.e16002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417702655"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24484"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2168"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090407"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160909500406"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.08.018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00122-F"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.03.006"},{"key":"e_1_2_6_15_1","volume-title":"Histological Typing of Salivary Gland Tumours: (WHO. 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