{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:49Z","timestamp":1772118769801,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We observed high survival in a previous report of a p16\u2010positive, oropharyngeal carcinoma (OPC) cohort treated primarily with transoral laser microsurgery (TLM)\u2009\u00b1\u2009adjuvant therapy and followed for\u2009\u2265\u200912 months. To address long\u2010term outcomes of primary transoral surgery for this unique disease, we present an updated analysis of our cohort with extended follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospectively assembled TLM cohort of 171 OPC patients was analyzed for disease\u2010free, disease\u2010specific, and overall survival (disease\u2010free survival [DFS], disease\u2010specific survival [DSS], overall survival [OS]) and functional outcomes, with a minimum follow\u2010up of 60 months or to death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow\u2010up was 103 (60\u2013201) months. Five\u2010year DFS, DSS, and OS estimates were 85% (95% confidence interval [CI]: 80%\u201391%), 93% (95% CI: 89%\u201397%), and 90% (95% CI: 86%\u201395%). Recurrence occurred in 20 (12%; 7 locoregional, 13 distant); median time to recurrence was 18.8 months; and 90% occurred within 48 months. Age, smoking, American Joint Committee on Cancer 8th edition clinical tumor\u2010category, pathologic tumor (pT)\u2010category, pathologic tumor\u2010node\u2010metastasis (pTNM), and any adjuvant were significantly associated with disease\u2010free survival in multivariable analyses, whereas pT\u2010category, pN\u2010category, TNM grouping, and angioinvasion were associated with DSS. A second primary developed in six (3.5%) patients. Indications for gastrostomy were recurrence\/second primary (11), postadjuvant esophageal stenosis (6), comorbidities (3), and osteo\/chondroradionecrosis (3); only seven (4%) had a gastrostomy tube in the absence of these factors, all of whom received adjuvant therapy. Two had a tracheostomy tube [chondoradionecrosis (1), recurrence (1)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      High 5\u2010year survival and locoregional control were observed, with recurrence occurring more commonly as distant metastasis. The observed time to recurrence suggests posttreatment oncologic surveillance for at least 48 months. Identified prognosticators will inform adjuvant treatment considerations, trial planning, and patient counseling for long\u2010term outcomes.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 2018\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2b\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 129:1141\u20131149, 2019\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.27472","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T07:22:54Z","timestamp":1535440974000},"page":"1141-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Long\u2010term analysis of transorally resected p16\u2009+\u2009Oropharynx cancer: Outcomes and prognostic factors"],"prefix":"10.1002","volume":"129","author":[{"given":"Parul","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine  St. Louis Missouri U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce H.","family":"Haughey","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Florida Hospital Celebration Health, Celebration  Florida U.S.A"},{"name":"Department of Surgery University of Auckland Faculty of Medicine and Health Sciences  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine  St. Louis Missouri U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan 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