{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:20:13Z","timestamp":1779916813039,"version":"3.53.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Computer\u2010assisted planning of osteotomy lines, coupled with navigation\u2010guided performance of planned osteotomies, is a highly innovative approach to skull\u2010base and orbital surgery.<\/jats:p><jats:p>The aim of this pilot study is to provide an assessment of the accuracy of this novel approach in guiding the correct positioning of osteotomy lines in frontal, temporal, and orbital regions, defining the agreement between the spatial position of the planned and performed osteotomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with orbital, frontal sinus, and lateral skull\u2010base diseases underwent virtual surgical planning. Osteotomies to access the orbit, frontal sinus, and lateral skull base were planned on computer tomography\u2010based three\u2010dimensional models. The planned osteotomies were reproduced on the operating field using a navigation system. The positions of the performed and planned osteotomies were compared. The results were described as the mean positional difference between planned and performed osteotomies and as Lin's concordance coefficient, and Bland\u2010Altman limits of agreement were also defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall mean difference was 0.719\u2009mm (95% confidence interval [CI]: 0.472 to 0.965\u2009mm). Overall, Lin's concordance coefficient was 0.997 (95% CI: 0.996 to 0.998), and overall Bland\u2010Altman limits of agreement ranged from \u22121.407 to 2.844\u2009mm.<\/jats:p><jats:p>The smallest mean difference (0.587\u2009mm, 95% CI: 0.244 to 0.931\u2009mm) was calculated in the orbit group, whereas the highest mean difference (0.904\u2009mm, 95% CI: 0.428 to 1.379\u2009mm) was described in the lateral skull\u2010base group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study's results support the use of this novel planning and navigation protocol for guiding osteotomy in anterior and lateral skull\u2010base surgery, providing a clinical validation of this technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 Laryngoscope, 00:1\u20139, 2018 <jats:italic>Laryngoscope<\/jats:italic>, 129:823\u2013831, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27479","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T11:12:24Z","timestamp":1535454744000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A novel approach to skull\u2010base and orbital osteotomies through virtual planning and navigation"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-4088","authenticated-orcid":false,"given":"Leonardo","family":"Franz","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, Academic Hospital of Udine, Department of Medicine, University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Academic Hospital of Udine, Department of Medicine, University of Udine  Udine 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