{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:43:03Z","timestamp":1761324183655},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P50 DC00422"],"award-info":[{"award-number":["P50 DC00422"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>There is a growing need to understand the underlying mechanisms of age\u2010related olfactory dysfunction with the increasing proportion of older adults over the next 20 years. Despite the importance of olfactory cleft (OC) volumes on odorant deposition and olfactory function, little is known about age\u2010related changes to OC volume. The goal of this study was to use automated techniques in a cross\u2010sectional design to investigate the extent to which OC volumes vary with age and determine the spatial specificity of any age\u2010related effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Deformation\u2010based morphometry was utilized to measure OC and sinus volumes in two independent samples of 101 (Medical University of South Carolina [MUSC] sample) and 95 (Hammersmith sample) healthy adults who underwent T1\u2010weighted magnetic resonance imaging, with the Hammersmith sample serving as a replication sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the MUSC and Hammersmith samples were 54.9 \u00b1 17.0 years and 52.1 years \u00b1 15.7 years, respectively. In both samples, there was a significant positive association between age and OC volume that occurred at a constant rate across the lifespan (Cohen's <jats:italic>f<\/jats:italic><jats:sup>2<\/jats:sup> of 0.065 in the MUSC sample and 0.110 in the Hammersmith sample). Age\u2010associated OC volume increases occurred in conjunction with decreases in sinus volumes as well as increases in non\u2010OC nasal cavity volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cross\u2010sectional study, there is an increase in OC volume with increasing age that occurs in the context of broad age\u2010associated differences in sinonasal anatomy. Future studies should investigate the impact of age\u2010associated differences in intranasal anatomy on nasal airflow, odorant deposition, and olfactory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 129:E55\u2013E60, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27505","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T16:55:26Z","timestamp":1539795326000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Age\u2010related differences in olfactory cleft volume in adults: A computational volumetric study"],"prefix":"10.1002","volume":"129","author":[{"given":"Mitchell L.","family":"Worley","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy R.","family":"Dubno","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and 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