{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:14Z","timestamp":1747150154270,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the cochleovestibular apparatus bilaterally in children with isolated unilateral bony cochlear nerve canal (bCNC) stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Imaging studies of children with unilateral bCNC stenosis (&lt;1.0\u2009mm) on computed tomography imaging (N\u2009=\u200936) were compared with controls imaged due to trauma without temporal bone injury (N\u2009=\u200932). Twenty\u2010six measurements were obtained in each ear, assessing the bony internal auditory canal (IAC), cochlea, and vestibular end\u2010organs, and were analyzed using one\u2010way analysis of variance for intersubject comparisons and paired <jats:italic>t<\/jats:italic> tests for intrasubject comparisons with a Bonferroni adjustment for multiple comparisons (<jats:italic>P<\/jats:italic>\u2009=\u2009.0006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with bCNC stenosis had a smaller IAC (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.000) and cochlea (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.000) on the stenotic si<jats:styled-content>d<\/jats:styled-content>e as compared with controls. Although the vestibular end\u2010organ was also smaller in bCNC ears, this difference was not significant. The contralateral ear also had a smaller bCNC (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.000) and cochlea (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.000) as compared with controls, although to a lesser degree than the stenotic side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with unilateral bCNC stenosis have abnormal biometry of both the cochlea and the vestibular end\u2010organ in the affected and the normal contralateral ear as compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:2403\u20132408, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27559","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T06:59:16Z","timestamp":1540364356000},"page":"2403-2408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Children with unilateral cochlear nerve canal stenosis have bilateral cochleovestibular anomalies"],"prefix":"10.1002","volume":"129","author":[{"given":"Luis D.","family":"Vilchez\u2010Madrigal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery National Children's Hospital  San Jose Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan I.","family":"Blaser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"},{"name":"Department of Diagnostic Imaging, Division of Neuroradiology Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus E.","family":"Wolter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian L.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blake C.","family":"Papsin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"},{"name":"Archie's Cochlear Implant Laboratory Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"},{"name":"Archie's Cochlear Implant Laboratory Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"},{"name":"Department of Communication Disorders Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-4510","authenticated-orcid":false,"given":"Sharon L.","family":"Cushing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"},{"name":"Archie's Cochlear Implant Laboratory Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-8530","authenticated-orcid":false,"given":"Evan J.","family":"Propst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital for Sick Children, University of Toronto  Toronto Ontario 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