{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:07Z","timestamp":1792270627032,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Knopp Biosciences, LLC."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) and eosinophilia is a disease of the upper respiratory tract for which few therapies are available. Because the oral investigational drug dexpramipexole serendipitously decreased blood eosinophils in amyotrophic lateral sclerosis studies, we assessed its safety, eosinophil\u2010lowering activity, and preliminary clinical efficacy in patients with CRSwNP and eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen subjects with CRSwNP, absolute eosinophil count (AEC)\u2009\u2265\u20090.300\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, and polyp tissue eosinophils were evaluable for efficacy in a 6\u2010month open\u2010label, multi\u2010center study of dexpramipexole 150\u2009mg twice daily. The coprimary endpoints were change in AEC and change in total polyp score (TPS) from baseline to month 6, with additional clinical and histologic endpoints assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen of 16 subjects completed 6 months of dexpramipexole treatment. Geometric mean baseline AEC was 0.525\u2009\u00b1\u20090.465 eosinophils\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L and decreased to 0.031\u2009\u00b1\u20090.019 after 6 months of dexpramipexole treatment, a 94% reduction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Ten of 16 subjects had eosinophil counts reduced to\u2009\u2264\u20090.020\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L at month 6. In 12 subjects with nasal polyp biopsies at baseline and month 6, tissue eosinophils were reduced from a mean of 168\u2009\u00b1\u2009134 to 5\u2009\u00b1\u20092 per high\u2010power field (HPF) (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), a 97% reduction from baseline. There was no significant reduction in TPS or improvement in other clinical endpoints. Dexpramipexole was well tolerated, with no drug\u2010related serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dexpramipexole treatment produced profound eosinophil\u2010lowering in peripheral blood and nasal polyp tissue. Despite the near\u2010elimination of polyp eosinophils, decreased TPS and nasal symptom improvement were not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 <jats:italic>Laryngoscope<\/jats:italic>, 129:E61\u2013E66, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27564","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T19:46:04Z","timestamp":1538768764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-9795","authenticated-orcid":false,"given":"Tanya M.","family":"Laidlaw","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Division of Rheumatology, Immunology, and Allergy  Boston 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Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Division of Rheumatology, Immunology, and Allergy  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Knopp Biosciences, LLC  Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Archibald","sequence":"additional","affiliation":[{"name":"Knopp Biosciences, LLC  Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven 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