{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:14:06Z","timestamp":1764260046499},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To further characterize the epidemiology, prognostic disease\u2010specific factors, and treatment outcomes\u2014including newly available chemotherapy data\u2014for patients with sinonasal diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results registry was queried from 1973 to 2015 for patients with DLBCL of the nasal cavity and paranasal sinuses. Demographic and disease parameters were collected. Prognostic disease\u2010specific survival and overall survival factors were evaluated with univariate Kaplan\u2010Meier analysis. Significant variables were analyzed with multivariate Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,273 cases of DLBCL of the sinonasal tract were identified. Significant differences in age of diagnosis between men (65.3) and women (71.1) existed (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Most common primary sites of DLBCL were maxillary sinus (36.1%) and nasal cavity (34.5%), with nasal cavity more common among Asian\/Pacific Islands (43.4%) and maxillary sinus more common for Caucasians (36.3%) and African Americans (42.1%). Overall survival was 70% at 2 years, 54% at 5 years, and 38% at 10 years. Disease\u2010specific survival was 81%, 73%, and 67%, respectively. Chemotherapy (hazard ratio [HR]: 0.551;<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and radiation therapy (HR: 0.818;<jats:italic>P<\/jats:italic>\u2009=\u2009.012) were associated with improved prognosis, whereas higher Ann Arbor stage worsened prognosis (HR: 1.21;<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Surgical intervention did not significantly impact survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to include chemoradiation therapy in population\u2010based analysis of sinonasal DLBCL. Chemotherapy and radiation therapy use significantly improve survival in these patients, whereas Ann Arbor staging is significantly associated with poorer outcomes. The mainstay of treatment for DLBCL should remain combination chemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:1259\u20131264, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27639","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T11:05:00Z","timestamp":1545303900000},"page":"1259-1264","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epidemiologic, prognostic, and treatment factors in sinonasal diffuse large B \u2010cell lymphoma"],"prefix":"10.1002","volume":"129","author":[{"given":"Antonios N.","family":"Varelas","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eggerstedt","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Ganti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130508400117"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970801)80:3<477::AID-CNCR16>3.0.CO;2-U"},{"key":"e_1_2_6_4_1","first-page":"6","article-title":"Non\u2010Hodgkin's lymphoma of nasal cavity and paranasal sinuses. A clinicopathological and immunohistochemical study","volume":"27","author":"Chalastras T","year":"2007","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.09.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.09.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25111"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0368-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.155"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.47102\/annals-acadmedsg.V33N4p15S","article-title":"Lymphomas involving Waldeyer's ring: placement, paradigms, peculiarities, pitfalls, patterns and postulates","volume":"33","author":"Tan L","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_11_1","first-page":"1057","article-title":"Non\u2010Hodgkin lymphomas of Waldeyer's ring","volume":"54","author":"Salplahta D","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/clon.1999.9088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29819"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9244-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-3-199708010-00002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7843"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-517292"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.722216"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.12.6005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28942"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu556"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200302000-00002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-3-319-13150-4_11","volume-title":"Non\u2010Hodgkin Lymphoma: Pathology, Imaging, and Current Therapy","author":"Kubuschok B","year":"2015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2018.6949"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14433"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.27639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T14:12:04Z","timestamp":1720879924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/lary.27639"],"URL":"https:\/\/doi.org\/10.1002\/lary.27639","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,20]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}