{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:07:53Z","timestamp":1773882473423,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To describe recurrence patterns in patients with recurrent respiratory papillomatosis (RRP) following surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center, retrospective, longitudinal case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Initial and follow\u2010up laryngoscopic examinations of seven previously untreated adult\u2010onset RRP patients were reviewed. Patients were followed longitudinally for periods ranging from 3 months to 7 years. Lesion locations were recorded using a twenty\u2010one region laryngeal schematic, and maps were generated to illustrate the distribution of disease before and after cold\u2010knife or potassium\u2010titanyl\u2010phosphate laser intervention. Univariate and multivariate analyses were employed to examine variables affecting recurrence patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across all patients, a statistically significant correlation between initial distribution and primary recurrence was observed. Seventy\u2010five percent of new lesions were adjacent to regions with preexisting disease; 83% of new glottic lesions were adjacent to preexisting glottic lesions, and 66% of supraglottic lesions were adjacent to preexisting supraglottic regions. No statistically significant differences in recurrence rate were observed across sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In previously untreated patients with adult\u2010onset recurrent respiratory papillomatosis, lesions tended to recur either in the same regions or regions adjacent to those affected at the time of initial surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:1993\u20131997, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27694","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T22:14:27Z","timestamp":1557180867000},"page":"1993-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Laryngeal distribution of adult\u2010onset recurrent respiratory papillomatosis: A longitudinal study"],"prefix":"10.1002","volume":"129","author":[{"given":"Lizbeth","family":"Hu","sequence":"first","affiliation":[{"name":"New York University Voice Center Department of Otolaryngology\u2013Head and Neck Surgery  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Benedict","sequence":"additional","affiliation":[{"name":"New York University Voice Center Department of Otolaryngology\u2013Head and Neck Surgery  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Garber","sequence":"additional","affiliation":[{"name":"New York University Voice Center Department of Otolaryngology\u2013Head and Neck Surgery  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population Heath, Division of Biostatistics New York University School of Medicine  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan R.","family":"Amin","sequence":"additional","affiliation":[{"name":"New York University Voice Center Department of Otolaryngology\u2013Head and Neck Surgery  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-9036","authenticated-orcid":false,"given":"Ryan C.","family":"Branski","sequence":"additional","affiliation":[{"name":"New York University Voice Center Department of Otolaryngology\u2013Head and Neck Surgery  New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200802"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890120044008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816628871"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816a7135"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01232.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26742"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1989.tb00364.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1983.tb01414.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25795"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198305263082104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.06.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(03)00007-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199806000-00026"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100603"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112001001"},{"key":"e_1_2_6_18_1","first-page":"CD005053","article-title":"Adjuvant antiviral therapy for recurrent respiratory papillomatosis","volume":"12","author":"Chadha NK","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198706000-00005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00874092"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.27694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:09:04Z","timestamp":1694164144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/lary.27694"],"URL":"https:\/\/doi.org\/10.1002\/lary.27694","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}