{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:40:04Z","timestamp":1777941604363,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03DC012429"],"award-info":[{"award-number":["R03DC012429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The purpose of this study was to determine the effects of octanoic acid on acoustic, perceptual, and functional aspects of essential voice tremor (EVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, double\u2010blind, placebo\u2010controlled, crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen participants with a diagnosis of EVT were randomized to a 3\u2010week dosing condition of octanoic acid or placebo, followed by a 2\u2010week washout period and crossover to the other condition for an additional 3 weeks. Baseline and post\u2010testing sessions were completed before and at the completion of each condition. Primary outcome measures were the magnitude of amplitude and frequency tremor, measured from the acoustic signal. Secondary outcomes were auditory\u2010perceptual ratings of tremor severity and self\u2010ratings of voice handicap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Magnitude of amplitude and frequency tremor were significantly lower after 3 weeks of octanoic acid dosing as compared to the placebo condition. Auditory\u2010perceptual ratings of tremor severity did not show significant differences between conditions. A trend toward better voice was seen for the sustained vowel ratings, but not the sentence\u2010level ratings. No significant differences between conditions were seen on self\u2010reported voice disability as assessed on the Voice Handicap Index\u201010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this controlled investigation support the potential utility of octanoic acid for reducing the magnitude of tremor in people with EVT. Further research is needed to determine whether different dosing or treatment combinations can improve functional communication in EVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:1882\u20131890, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27695","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T06:58:28Z","timestamp":1545807508000},"page":"1882-1890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Effect of Octanoic Acid on Essential Voice Tremor: A Double\u2010Blind, Placebo\u2010Controlled Study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-8122","authenticated-orcid":false,"given":"Soren Y.","family":"Lowell","sequence":"first","affiliation":[{"name":"Department of Communication Sciences and Disorders Syracuse University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences State University of New York Upstate Medical University, Syracuse  New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Monahan","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders Syracuse University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly Jo","family":"Hosbach\u2010Cannon","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders Syracuse University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond H.","family":"Colton","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders Syracuse University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragos","family":"Mihaila","sequence":"additional","affiliation":[{"name":"Department of Neurology State University of New York Upstate Medical University, Syracuse  New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"OrtmanJM VelkoffVA HoganH.An aging nation: the older population in the united states: population estimates and projections. 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