{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:13:23Z","timestamp":1772986403732,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing the significance of IGLN metastasis in local control (LC) of parotid gland cancer (PGC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, IGLN metastasis, and follow\u2010up findings was extracted and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IGLN metastasis was noted in 111 (32.9%) patients. Tumor stage, pathologic nodal stage, perineural invasion, resection status, and lymphovascular invasion were significantly related to IGLN metastasis. Local recurrence was noted in 67 (19.9%) patients. IGLN metastasis was an independent predictor of LC. The 10\u2010year LC rate was 94% for patients without IGLN metastasis, 56% for patients with metastasis in no more than two IGLNs, and 22% for patients with metastasis in more than two IGLNs. This difference was significant (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The IGLN metastasis rate is relatively high in PGC patients and is significantly associated with disease grade and T stage. IGLN metastasis is associated with poorer local LC, and patients with more than two metastatic nodes have the worst prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:2309\u20132312, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27701","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T13:38:35Z","timestamp":1544794715000},"page":"2309-2312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Significance of intraparotid node metastasis in predicting local control in primary parotid cancer"],"prefix":"10.1002","volume":"129","author":[{"given":"Yanping","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Oral Medicine the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-1030","authenticated-orcid":false,"given":"Qigen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-701X","authenticated-orcid":false,"given":"Xinyu","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10400"},{"key":"e_1_2_6_3_1","volume-title":"World Health Organization classification of tumours. 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