{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:50:00Z","timestamp":1792518600617,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tri-Service General Hospital, Taipei, Taiwan","award":["TSGH-C106-031 to C.-P.S.TSGH-C107-009 to C.-H.W. TSGH-C107-024 to C.-H.W."],"award-info":[{"award-number":["TSGH-C106-031 to C.-P.S.TSGH-C107-009 to C.-H.W. 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The above\u2010mentioned manipulations were performed 2 hours prior to white noise exposure. The cochlear damage, including auditory threshold shifts, hair cell loss, and expression of cochlear HMGB1, was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The enhanced DEX delivery efficiency of the USM group was approximately 2.4\u00d7 to 11.2\u00d7 greater than that of the RWS group. After the noise exposure, the RWS group showed significant cochlear protection compared with the control group, and more significant and dominant protective effects were demonstrated in the USM group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of US\u2010MBs provides a safe and more effective approach than spontaneous diffusion, which is commonly used in clinical practice; thus, this technique holds potential for future inner\u2010ear drug delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:1907\u20131914, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27713","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T09:10:27Z","timestamp":1545901827000},"page":"1907-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Middle\u2010ear dexamethasone delivery via ultrasound microbubbles attenuates noise\u2010induced hearing loss"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-2509","authenticated-orcid":false,"given":"Cheng\u2010Ping","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-5621","authenticated-orcid":false,"given":"Hsin\u2010Chien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang\u2010Kang","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of 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