{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:02:01Z","timestamp":1789851721416,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To review available information regarding in\u2010office procedures for benign vocal fold lesions (BVFL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed term search on office\/awake laryngeal procedures for any of the following specific lesions: Reinke's edema (RE), polyps, nodules, varices, vocal process granuloma, and vocal fold (VF) scar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In\u2010office ablative and nonablative laser procedures have been described for BVFL, including RE, polyps, varices, and granuloma. Fiber\u2010based lasers used include potassium titanyl phosphate, pulsed dye laser, and more recently CO<jats:sub>2<\/jats:sub>. In\u2010office intralesional steroid injection (ISI) for BVFL targets the inflammatory process involved with the lesion and may induce regression of polyps, nodules, RE, and granuloma. Botulinum toxin\u2010induced \u201cvoice rest\u201d has been described as adjunctive treatment for refractory VF nodules or vocal process granuloma. Most in\u2010office techniques for treating BVFL rely on induction of lesion regression rather than complete lesion removal, as in conventional operative microsurgery. When treating VF scarring, in\u2010office procedures aim to alter the wound\u2010healing process; ISI targets the inflammatory phase and angiolytic lasers target the proliferative phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In\u2010office procedures for BVFL apply new technology that can potentially lower risk and cost. Although numerous case series have shown the potential of these procedures, data that thoroughly compares outcomes with those of microlaryngoscopic techniques is needed.<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:2131\u20132138, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27731","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T17:50:11Z","timestamp":1545414611000},"page":"2131-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["In\u2010office procedures for the treatment of benign vocal fold lesions in the awake patient: A contemporary review"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-2940","authenticated-orcid":false,"given":"Hagit","family":"Shoffel\u2010Havakuk","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Sackler 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