{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:00:53Z","timestamp":1793642453570,"version":"4.5.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA90731"],"award-info":[{"award-number":["R01 CA90731"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Literature examining long\u2010term survival in head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV) status is lacking. We compare 10\u2010year overall survival (OS) rates for cases to population\u2010based controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases surviving 5 years postdiagnosis were identified from the Carolina Head and Neck Cancer Study. We examined 10\u2010year survival by site, stage, p16, and treatment using Kaplan\u2010Meier and Cox proportional hazard models. Cases were compared to age\u2010matched, noncancer controls with stratification by p16 and smoking status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten\u2010year OS for HNSCC is less than controls. In 581 cases, OS differed between sites with p16+ oropharynx having the most favorable prognosis (87%), followed by oral cavity (69%), larynx (67%), p16\u2212 oropharynx (56%), and hypopharynx (51%). Initial stage, but not treatment, also impacted OS. When compared to controls matched on smoking status, the hazard ratio (HR) for death in p16+ oropharynx cases was 1.5 (95% confidence interval [CI]: 0.7\u20103.1) for smokers and 2.4 (95% CI: 0.7\u20108.8) for nonsmokers. Similarly, HR for death in non\u2013HPV\u2010associated HNSCC was 2.2 (95% CI: 1.7\u20103.0) for smokers and 2.4 (95% CI: 1.4\u20104.9) for nonsmokers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OS for HNSCC cases continues to decrease 5 years posttreatment, even after stratification by p16 and smoking status. Site, stage, smoking, and p16 status are significant factors. These data provide important prognostic information for HNSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 129:2506\u20132513, 2019\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.27807","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T02:39:58Z","timestamp":1547433598000},"page":"2506-2513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":239,"title":["Long\u2010term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-9857","authenticated-orcid":false,"given":"Eugenie","family":"Du","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Mazul","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine in St. Louis  St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brennan","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasena","family":"Anantharaman","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"},{"name":"Cancer Research Program (HPV Research) Rajiv Gandhi Centre for Biotechnology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnoush","family":"Abedi\u2010Ardekani","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Weissler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."},{"name":"Department of Medicine Division of Hematology and OncologyUniversity of Tennessee Health Science Center  Memphis Tennessee U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina U.S.A."},{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-6767","authenticated-orcid":false,"given":"Jose P.","family":"Zevallos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine in St. Louis  St. Louis Missouri U.S.A."},{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina 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