{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:04:58Z","timestamp":1791986698409,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Nasal polyps are often characterized by type 2 inflammation and disease recurrence. We developed a new surgical technique, referred to as <jats:italic>reboot approach<\/jats:italic>, which aims to maximally remove all sinus mucosa and allow healthy re\u2010epithelialization from the preserved nasal mucosa. We here review type 2 endotype chronic rhinosinusitis with nasal polyps (CRSwNP) patients who underwent classical mucosa\u2010sparing endoscopic sinus surgery (ESS) or the reboot approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case\u2010control study of 50 consecutive CRSwNP patients who underwent endoscopic sinus surgery between 2015 and 2017, either as a classical non\u2010reboot ESS (n = 20); a partial reboot approach removing the mucosa of the ethmoidal, sphenoidal, and maxillary sinuses (n = 18); or a complete reboot approach including Draf III and removal of all frontal sinus mucosa (n = 12). Polyp recurrence over the follow\u2010up period of 2 years served as the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients demonstrated a type 2 inflammation of the mucosal tissue harvested during surgery. In the classical approach group (n = 20), nine patients relapsed within 2 years (45%); in the partial reboot group, three out of 18 patients (17%) relapsed; and in the full reboot group one out of 12 patients (8%) relapsed. The relapse rates were significantly different between the non\u2010reboot and the reboot groups (<jats:italic>P<\/jats:italic> = 0.02) but also between all treatment groups (<jats:italic>P<\/jats:italic> = 0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Complete removal of diseased mucosa from the paranasal sinuses (reboot approach) significantly reduces the recurrence of nasal polyps for 30 months postoperatively compared to the current mucosa\u2010sparing approach in type 2 inflammatory CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:1286\u20131292, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27815","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T08:15:47Z","timestamp":1548058547000},"page":"1286-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Endoscopic Sinus Surgery for Type\u20102 CRS wNP: An Endotype\u2010Based Retrospective Study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-6600","authenticated-orcid":false,"given":"Saeed","family":"Alsharif","sequence":"first","affiliation":[{"name":"Upper Airway Research Laboratory, Department of Otorhinolaryngology Ghent University  Ghent Belgium"},{"name":"Department of Otolaryngology, Supply Base Saudi Royal Army  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Jonstam","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Division of Ear Nose and Throat Diseases, Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Ear, Nose and Throat Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"van Zele","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory, Department of Otorhinolaryngology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory, Department of Otorhinolaryngology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Holtappels","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory, Department of Otorhinolaryngology Ghent University  Ghent 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