{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:22:27Z","timestamp":1787984547870,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Sialorrhea is excessive saliva production and its usual escape of from the oral cavity. The use of botulinum toxin has been preconized, but its effectiveness until now has been unreliably measured. Our objective was to qualitatively and quantitatively determine the effectiveness of botulinum toxin injection in the reduction of saliva production by the parotid gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Outcomes research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with moderate\u2010to\u2010critical sialorrhea had one of the parotid glands injected with 50 U of botulinum toxin, leaving the other as the control. Fifteen days after the toxin injection, they underwent scintigraphic analyses with intravenous injection of 10 mCi (37 MBq) of Tc\u201099 m (sodium pertechnetate). After this, the noninjected gland was treated for therapeutic complementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The glands injected with botulinum toxin showed uptake reduction in 100% of patients. The uptake reduction in counts per second varied from 8% to 36%. The Wilcoxon paired test comparing the control glands with those injected showed a significant difference for the action of botulinum toxin (<jats:italic>P<\/jats:italic> = .0039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The scintigraphic study of parotid glands shows that botulinum toxin is effective in reducing sodium pertechnetate uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2c <jats:italic>Laryngoscope<\/jats:italic>, 129:2521\u20132526, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27826","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T08:15:03Z","timestamp":1548749703000},"page":"2521-2526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Qualitative and quantitative scintigraphy in sialorrhea before and after botulinum toxin injection"],"prefix":"10.1002","volume":"129","author":[{"given":"Livia Barroso","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Medicina F\u00edsica e Reabilita\u00e7\u00e3o Hospital Universit\u00e1rio Clementino Fraga Filho Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Rodrigues","family":"Xerez","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina F\u00edsica e Reabilita\u00e7\u00e3o Hospital Universit\u00e1rio Clementino Fraga Filho Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelindo","family":"Maliska","sequence":"additional","affiliation":[{"name":"Departamento de Radiologia Faculdade de Medicina Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-4805","authenticated-orcid":false,"given":"Sergio Augusto Lopes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Departamento de Radiologia Faculdade de Medicina Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Melciades Barbosa","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Laborat\u00f3rio de Motilidade Digestiva e Imagem Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.01.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5051010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.03.009"},{"key":"e_1_2_6_5_1","first-page":"7","volume-title":"An Essay on the Shaking Palsy","author":"Parkinson J","year":"1817"},{"key":"e_1_2_6_6_1","first-page":"2628","article-title":"Gendron k, Handler SD. 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