{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:11:55Z","timestamp":1773094315611,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA097007\u201010"],"award-info":[{"award-number":["P50CA097007\u201010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56DE025248\u201001"],"award-info":[{"award-number":["R56DE025248\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DE025248\u201001"],"award-info":[{"award-number":["1R01DE025248\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity\u2010modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1\u2009N0 glottic squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty\u2010three patients (71%) were treated using ConRT and 62 (29%) using IMRT. The median follow\u2010up for all patients was 68\u2009months. There was no statistically significant difference in 5\u2010year local control between patients with T1a versus T1b disease (94% vs. 89%, respectively, <jats:italic>P<\/jats:italic> =\u20090.5). Three\u2010year locoregional control for patients treated with ConRT was 94% compared to 97% with IMRT (<jats:italic>P<\/jats:italic> =\u20090.4). Three\u2010year overall survival (OS) for patients treated with ConRT was 92.5% compared with 100% with IMRT (<jats:italic>P<\/jats:italic> =\u20090.1). Twelve of 14 patients with local recurrence underwent salvage surgery with 5\u2010year ultimate locoregional control of 98.5% and 97.1% in the ConRT and IMRT cohorts, respectively (<jats:italic>P<\/jats:italic> =\u20090.7). Multivariate analysis showed age\u2009&lt;\u200960\u2009years (<jats:italic>P<\/jats:italic> &lt;\u20090.0001) and pretreatment Eastern Cooperative Oncology Group performance status &lt;2 (<jats:italic>P<\/jats:italic> =\u20090.0022) to be independent correlates of improved OS. Postradiation cerebrovascular events were in four patients in the ConRT cohort (3%), whereas no patients in the IMRT cohort suffered any events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because the oncologic outcomes for patients treated with IMRT were excellent and IMRT allows for carotid sparing, we have transitioned to IMRT as our standard for most patients with T1 glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b <jats:italic>Laryngoscope<\/jats:italic>, 130:146\u2013153, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27873","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T08:29:00Z","timestamp":1550046540000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Outcomes of carotid\u2010sparing IMRT for T1 glottic cancer: Comparison with conventional radiation"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-7613","authenticated-orcid":false,"given":"Abdallah S.R.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"},{"name":"Department of Clinical Oncology University of Alexandria  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaine D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"},{"name":"University of Texas McGovern Medical School The University of Texas Graduate School of Biomedical Sciences  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-669X","authenticated-orcid":false,"given":"Joshua B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"},{"name":"University of Texas McGovern Medical School The University of Texas Graduate School of Biomedical Sciences  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag","family":"Sevak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica S.","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aasheesh","family":"Kanwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Browne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Brandon","family":"Gunn","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S.","family":"Garden","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Frank","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Phan","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Zafereo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center  Houston Texas U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heath","family":"Skinner","sequence":"additional","affiliation":[{"name":"Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas 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