{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:55:09Z","timestamp":1790297709375,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Timing and indication for surgical intervention is a major challenge in managing pediatric oropharyngeal dysphagia. No study has evaluated a natural course of swallowing dysfunction in otherwise healthy infants. Our objective was to review the outcomes and time to resolution of abnormal swallow in infants with aspiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series at a tertiary children's hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients under 1\u2009year old with aspiration on a modified barium swallow study were included. Patients born &lt;34\u2009weeks, with medical or genetic comorbidities, or who underwent surgical intervention for aspiration were excluded. Patients were followed until aspiration resolved on a swallow study. Kaplan\u2010Meier survival analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients (25 patients [50%] by 6\u2009months, 10 [20%] by 1\u2009year, three [6%] by 2\u2009years, and two [4%] at the end of the follow\u2010up interval) were recommended a normal diet, and 10 patients (20%) were still aspirating by the end of the follow\u2010up interval. Median time to resolution was 202\u2009\u00b1\u20097\u2009days (range, 19\u2013842\u2009days), probability 48% (95% confidence interval [CI]: 0.34\u20100.62). The probability of resolution at 6\u2009months was 46% (95% CI: 0.4\u20100.68), at 1\u2009year was 64% (95% CI: 0.51\u20100.77), at 2\u2009years was 76% (95% CI: 0.64\u20100.88), and at the end of the follow\u2010up interval 81.3% (95% CI: 0.7\u20100.92).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of infants with aspiration and without any other major comorbidities improved within 1\u2009year. Future research should be directed toward better understanding swallowing dysfunction in neurologically normal infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 130:514\u2013520, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27888","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T03:01:06Z","timestamp":1551841266000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Aspiration in the otherwise healthy Infant\u2014Is there a natural course for improvement?"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-3601","authenticated-orcid":false,"given":"Geoffrey C.","family":"Casazza","sequence":"first","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elise","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Asfour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Skirko","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Meier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City Utah U.S.A"},{"name":"Primary Children's Hospital  Salt Lake City Utah 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