{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:43:11Z","timestamp":1790649791674,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The objective of this study was to report for the first time on the results of submucosal injections of bevacizumab used in conjunction with cyanoacrylate glue sclerotherapy in hereditary hemorrhagic telangiectasia (HHT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analytic chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a chart review that included all patients with HHT treated with intranasal bevacizumab and cyanoacrylate glue for refractory epistaxis at Lariboisiere University Hospital from 2013 with a minimum follow\u2010up of 6\u2009months. We injected 100\u2009mg (25\u2009mg\/mL) of bevacizumab diluted in 2\u2009mL of serum at the base of the telangiectasias, and sclerotherapy with an injection of cyanoacrylate glue was used adjunctively. Treatment efficacy was based on changes in Epistaxis Severity Scores (ESS) and the Bergler\u2010Sadick Scale. Quality of life and patient satisfaction were evaluated using the Cantril Self\u2010Anchoring Ladder (CL) and Likert scale, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients were included, with a mean follow\u2010up of 26.6\u2009months. The average ESS score significantly decreased from 7.82 to 3.89 (<jats:italic>P<\/jats:italic> &lt;\u2009.05). The Bergler\u2010Sadick score significantly improved (<jats:italic>P<\/jats:italic> &lt;\u2009.05) following the treatment, including the frequency (from 2.74 to 1.64) and the quantity (from 2.54 to 1.51) scales. Quality of life was significantly improved (<jats:italic>P<\/jats:italic> &lt;\u2009.05) using the CL score (from 4.16 to 7.22). The Likert satisfaction scale related to the treatment efficacy was high, with an average of 7.03 out of 10. No complications were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Submucosal injections of bevacizumab in conjunction with cyanoacrylate glue sclerotherapy significantly reduced epistaxis and improved the quality of life in HHT. Prospective comparative studies are needed to further evaluate the significance of this treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 129:2210\u20132215, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27889","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:41:33Z","timestamp":1569904893000},"page":"2210-2215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Injection of bevacizumab and cyanoacrylate glue for hereditary hemorrhagic telangiectasia"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-0485","authenticated-orcid":false,"given":"Nadim","family":"Khoueir","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Skull Base Surgery Hospital Groups Saint Louis, Lariboisi\u00e8re, Fernand\u2010Widal, Public Assistance Paris Hospitals, Paris\u2010Diderot University  Paris France"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hotel Dieu de France University Hospital, Saint Joseph University, Faculty of Medicine  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Borsik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Skull Base Surgery Hospital Groups Saint Louis, Lariboisi\u00e8re, Fernand\u2010Widal, Public Assistance Paris Hospitals, Paris\u2010Diderot University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domitille","family":"Camous","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Skull Base Surgery Hospital Groups Saint Louis, Lariboisi\u00e8re, Fernand\u2010Widal, Public Assistance Paris Hospitals, Paris\u2010Diderot University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Skull Base Surgery Hospital Groups Saint Louis, Lariboisi\u00e8re, Fernand\u2010Widal, Public Assistance Paris Hospitals, Paris\u2010Diderot University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Skull Base Surgery Hospital Groups Saint Louis, Lariboisi\u00e8re, Fernand\u2010Widal, Public Assistance Paris Hospitals, Paris\u2010Diderot University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000814)93:4<320::AID-AJMG12>3.0.CO;2-R"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"e_1_2_6_5_1","first-page":"575","article-title":"Does the genotype ofHHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF?","volume":"22","author":"Sadick H","year":"2008","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03860.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3263"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino09.138"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.090"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1721-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2016.09.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.07.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0561-x"},{"key":"e_1_2_6_14_1","first-page":"591","article-title":"Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia","volume":"15","author":"Sadick H","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_15_1","first-page":"818","article-title":"Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor\u2010beta1 as well as highALK1 tissue expression","volume":"90","author":"Sadick H","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00195-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20159"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26363"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20818"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23303"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12821"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25669"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.35"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0116-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115000365"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23736"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780280027001"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.02.010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.019"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154749.09303.e0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100136370"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21046"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4163"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111001733"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24303"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3809"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21099"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-11-0809"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2131"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198203000-00017"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-07-0425"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20065"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-012-0840-5"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32834a040c"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3182429866"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21587"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11724"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4427"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22501"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23655"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21374"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0150-9861(04)96977-5"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26722"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21345"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23230"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11387"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.27889","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:26:35Z","timestamp":1694240795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/lary.27889"],"URL":"https:\/\/doi.org\/10.1002\/lary.27889","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}