{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:36:01Z","timestamp":1790444161568,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically characterize and describe voice and swallowing manifestations in patients with X\u2010linked dystonia parkinsonism (XDP) and correlate with quality\u2010of\u2010life (QOL) measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four patients with XDP with communication and swallowing difficulties underwent neurological examination, head and neck examination, nasopharyngoscopy, QOL surveys (Swallowing Quality of Life questionnaire [SWAL\u2010QOL] and Voice Handicap Index [VHI]), and functional endoscopic evaluation of swallowing (FEES) to assess the extent of dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients showed high rates of lingual, oromandibular, and laryngeal dysfunction, as well as severe QOL changes in swallowing and communication ability. The most common head and neck manifestations of dystonic symptoms were difficulty coordinating the mouth and tongue (79%), uncontrollable tongue thrusting (53%), and jaw opening (35%). Laryngeal symptoms including vocal strain (adductor voice breaks) or stridor (32%), as well as velopharyngeal insufficiency (20%), were also identified. Of the patients with laryngeal symptoms, 18% had respiratory dystonia. Swallowing assessments showed significant abnormalities in oral bolus control and oropharyngeal dysphagia. FEES examinations showed that 87.5% of the study group had penetration or aspiration. QOL scores showed an average VHI of 94.4 (severe dysfunction), and SWAL\u2010QOL showed an average of 37.7 (severe dysfunction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Swallowing and voice impairment in XDP is not well characterized and presents a more distinctive phenomenology than other neurological disorders, with a unique set of challenges for treatment. This is the first study to systematically evaluate laryngeal and pharyngeal dysfunction in XDP patients and correlate with QOL measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 130:171\u2013177, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27897","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T03:59:49Z","timestamp":1553054389000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Voice and swallowing dysfunction in X\u2010linked dystonia parkinsonism"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-5441","authenticated-orcid":false,"given":"Phillip C.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoai","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Acuna","sequence":"additional","affiliation":[{"name":"The Collaborative Center for X\u2010linked Dystonia Parkinsonism Department of Neurology, Massachusetts General Hospital  Boston Massachusetts U.S.A."},{"name":"Sunshine Care Foundation  Roxas City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Kristopher Palentinos","family":"De Guzman","sequence":"additional","affiliation":[{"name":"The Collaborative Center for X\u2010linked Dystonia Parkinsonism Department of Neurology, Massachusetts General Hospital  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutan","family":"Sharma","sequence":"additional","affiliation":[{"name":"The Collaborative Center for X\u2010linked Dystonia Parkinsonism Department of Neurology, Massachusetts General Hospital  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor N.","family":"Francouer","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisela E.","family":"Dy","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital\/Massachusetts General Hospital  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Criscely L.","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Neurology Jose R. Reyes Memorial Medical Center  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"362","article-title":"Sex linked recessive dystonia parkinsonism of Panay, Philippines (XDP)","volume":"54","author":"Lee LV","year":"2001","journal-title":"Mol Pathol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199105000-00002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(02)00042-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.56"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10271"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2010.526728"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2011.558260"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.10009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090307"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2010.526729"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.292"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1831949100"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.292"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2611"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.09.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.10.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.01.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409230600648736"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/512129"},{"key":"e_1_2_7_21_1","volume-title":"GeneReviews","author":"Evidente VGH","year":"2015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2010.541573"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02414429"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000815"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.08.001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00008"},{"key":"e_1_2_7_27_1","first-page":"89","article-title":"Gold Standard? Analysis of the videofluoroscopic and fiberoptic endoscopic swallow examinations","volume":"3","author":"Rao N","year":"2003","journal-title":"J Appl Res Clin Exp Ther"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400309"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-001-0109-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-002-0073-4"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.01.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2005.12.019"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-015-9671-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afl105"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9245-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)80006-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-8758"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9700-3"}],"updated-by":[{"DOI":"10.1002\/lary.28915","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000}}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.27897","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T19:32:37Z","timestamp":1694201557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/lary.27897"],"URL":"https:\/\/doi.org\/10.1002\/lary.27897","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/lary.28915","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}