{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:02:29Z","timestamp":1774987349817,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["NRF-2018R1C1B5043458"],"award-info":[{"award-number":["NRF-2018R1C1B5043458"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we assessed the effectiveness of a tonsil\u2010derived mesenchymal stem cell (TMSC)\u2010transplanted polycaprolactone\/beta\u2010tricalcium phosphate prosthesis (specifically designed for easier fixing and grafting with a single scaffold) on rabbit mandible osteogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mandibles of 18 rabbits were exposed, and 10\u2009\u00d7\u20098\u2010mm bone defects were made. Two rabbits did not receive implants; four were reconstructed with the scaffold control (SC) (SC group); four were reconstructed with scaffolds soaked in peripheral blood (PB) (PB group); four were reconstructed with TMSC\u2010transplanted scaffolds (TMSC group); and four were reconstructed with differentiated osteocyte\u2010transplanted scaffolds (DOC) (DOC group). Each rabbit was sacrificed 12\u2009weeks after surgery, and the area of new bone formation was investigated by mechanical testing, histology, and micro\u2010computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More extended and denser new bone masses were observed in the TMSC and DOC groups, although fibrosis and vascular formation levels were similar in all groups, suggesting that the dual\u2010structured scaffold alone provides a good environment for bone attachment and regeneration. The bone volumes of representative scaffolds from the SC, PB, TMSC, and DOC groups were 43.12, 48.35, 53.10, and 57.44% of the total volumes, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The design of the scaffold resulted in effective osteogenesis, and TMSCs showed osteogenic potency, indicating that their combination could enable effective bone regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 130:358\u2013366, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27908","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T20:05:10Z","timestamp":1552421110000},"page":"358-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A 3D\u2010printed polycaprolactone\/\u03b2\u2010tricalcium phosphate mandibular prosthesis: A pilot animal study"],"prefix":"10.1002","volume":"130","author":[{"given":"Jae Hong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine, Soonchunhyang University  Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Yeon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine, Ewha Womans University  Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Kyou","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine, Soonchunhyang University  Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-2422","authenticated-orcid":false,"given":"Myung Jin","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of 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