{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:42:57Z","timestamp":1775576577977,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005193","name":"American Academy of Otolaryngology-Head and Neck Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001252","name":"Mount Zion Health Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","award":["Resource Allocation Program"],"award-info":[{"award-number":["Resource Allocation Program"]}],"id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate differences in cortical\u2010basal ganglia\u2010cerebellar functional connectivity between treated unilateral vocal fold paralysis (UVFP) and healthy control cohorts using resting\u2010state functional magnetic resonance imaging (RS\u2010fMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten UVFP study patients treated by type I thyroplasty and 12 control subjects underwent RS\u2010fMRI on a 3\u2010Tesla scanner to evaluate differences in functional connectivity of whole\u2010brain networks. Spontaneous RS\u2010fMRI data were collected using a gradient echo planar pulse sequence, preprocessed, and analyzed to compare seed\u2010to\u2010voxel maps between the two cohorts. Seeds were placed in the caudate, putamen, and globus pallidus divisions of the basal ganglia in both hemispheres. Group contrasts were tested for statistical significance using two\u2010tailed unpaired <jats:italic>t<\/jats:italic> tests corrected for multiple comparisons with a cluster false discovery rate threshold of <jats:italic>P<\/jats:italic> &lt; .05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UVFP patients demonstrated increased connectivity between both caudate nuclei and the precuneus, a node of the default mode network, compared to healthy controls. Both caudate nuclei also showed decreased connectivity with the left cerebellar hemisphere. The putamen and globus pallidus divisions of the basal ganglia were not abnormally connected to other brain structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UVFP patients treated by type I thyroplasty exhibited long\u2010term alterations of cortical\u2010basal ganglia\u2010cerebellar networks thought to be important for self\u2010referential voice quality awareness and learning processes that compensate for changes to the paralyzed hemilarynx. This pilot study on relatively small cohorts adds to growing evidence for persistent central nervous system changes in treated UVFP. Replication studies with larger numbers of subjects will be essential to validate and extend findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b <jats:italic>Laryngoscope<\/jats:italic>, 130:460\u2013464, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28004","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T17:28:51Z","timestamp":1557422931000},"page":"460-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cortical\u2010Basal Ganglia\u2010Cerebellar Networks in Unilateral Vocal Fold Paralysis: A Pilot Study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-7514","authenticated-orcid":false,"given":"Philip L.","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine L.","family":"Cueva","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-1086","authenticated-orcid":false,"given":"Clark A.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-8290","authenticated-orcid":false,"given":"VyVy N.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly L.","family":"Naunheim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-4547","authenticated-orcid":false,"given":"Katherine C.","family":"Yung","sequence":"additional","affiliation":[{"name":"San Francisco Voice and Swallowing University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Mizuiri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."},{"name":"Department of Radiology and Biomedical Imaging University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Houde","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California 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