{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:27Z","timestamp":1792782327394,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T00:00:00Z","timestamp":1555200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vesale Grant","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,3]]},"abstract":"\n Objectives\/Hypothesis<\/jats:title>\n To develop and validate the Reflux Symptom Score (RSS), a self\u2010administered patient\u2010reported outcome questionnaire for patients with laryngopharyngeal reflux (LPR).<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Prospective controlled study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 113 patients with LPR were enrolled and treated with diet and 3 months of pantoprazole, alginate, and\/or magaldrate depending on the LPR characteristics (acid, nonacid, or mixed). Eighty asymptomatic individuals completed the study. Patients and controls completed the RSS twice within a 7\u2010day period to assess test\u2010retest reliability. Internal consistency was measured using Cronbach's \u03b1 for the RSS items in patients and controls. Validity was assessed by comparing the baseline RSS with the Reflux Symptom Index (RSI) and Voice Handicap Index (VHI). Seventy\u2010seven patients completed the RSS at baseline and after 6 and 12 weeks of treatment to assess responsiveness to change. The RSS cutoff for determining the presence and absence of LPR was examined by receiver operating characteristic analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Test\u2010retest reliability (r\n s<\/jats:sub>\n = 0.921) and internal consistency reliability (\u03b1 = 0.969) were high. RSS exhibited high external validity indicated by a significant correlation with the RSI (r\n s<\/jats:sub>\n = 0.831). Internal validity was excellent based on the higher RSS in patients compared with controls (\n P<\/jats:italic>\n = .001). RSS, RSI, and VHI scores significantly improved from pre\u2010 to posttreatment, indicating a high responsiveness to change. RSS >13 can be considered suggestive of LPR\u2010related symptoms. RSS was not influenced by the occurrence of gastroesophageal reflux disease, LPR subtypes, or patient characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n RSS is a self\u2010administered patient\u2010reported outcome questionnaire that demonstrates high reliability and excellent criterion\u2010based validity. RSS can be used in diagnosing and monitoring LPR disease.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3b<\/jats:p>\n \n Laryngoscope<\/jats:italic>\n , 130:E98\u2013E107, 2020\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.28017","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T02:52:23Z","timestamp":1555296743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Validity and reliability of the reflux symptom score"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Laboratory of Anatomy and Cell Biology, Faculty of Medicine Research Institute for Health Sciences and Technology, University of Mons (UMons) Mons Belgium"},{"name":"Laboratory of Phonetics, Faculty of Psychology Research Institute for Language Science and Technology, University of Mons (UMons) Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Bobin","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Polyclinique de Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy CHU Saint\u2010Pierre, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Huet","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Laboratory of Phonetics, Faculty of Psychology Research Institute for Language Science and Technology, University of Mons (UMons) Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Harmegnies","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Laboratory of Phonetics, Faculty of Psychology Research Institute for Language Science and Technology, University of Mons (UMons) Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dapri","sequence":"additional","affiliation":[{"name":"Department of Surgery CHU Saint\u2010Pierre, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Therese","family":"Mar\u00e9chal","sequence":"additional","affiliation":[{"name":"Department of Surgery CHU Saint\u2010Pierre, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Finck","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Li\u00e8ge (Sart Tilman) Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rodriguez Ruiz","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists of the International Federation of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Marseille France"},{"name":"Laboratory of Anatomy and Cell Biology, Faculty of Medicine Research Institute for Health Sciences and Technology, University of Mons (UMons) Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU 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