{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:08:16Z","timestamp":1789110496285,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Topical mitomycin\u2010C (MMC) application is a commonly accepted adjuvant therapy in the surgical treatment for laryngotracheal stenosis (LTS). However, the efficacy of MMC has not been examined in a prospective, randomized clinical trial in humans. We aimed to examine the efficacy of MMC in the treatment of LTS patients as compared to a placebo\u2010controlled group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, randomized, double\u2010blind, placebo\u2010controlled clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with LTS were enrolled in a 24\u2010month trial and randomized into one of two groups: 1) endoscopic surgical treatment with topical application of MMC or 2) endoscopic surgical treatment with topical application of saline. Postoperatively, patients were evaluated at standardized intervals with a symptom questionnaire and spirometry. Subsequent surgery was performed as needed based on relapse of stenosis on exam and patient\u2010reported symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average interval between surgical treatments was 17.9 months in the placebo group and 17.4 months in the MMC group (<jats:italic>P<\/jats:italic> = .95). There was no difference in magnitude of peak inspiratory flow (PIF) improvement between groups. The average magnitude of PIF change was 1.3 L\/sec and 1.1 L\/sec for the placebo and MMC groups, respectively (<jats:italic>P<\/jats:italic> = .64). Similarly, there was no difference in magnitude of symptom improvement or duration of symptom improvement between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective, randomized. double\u2010blind. placebo\u2010controlled trial suggests that the use of MMC as a topical adjuvant therapy has no additional benefit in the endoscopic surgical management of LTS. Further study is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 130:706\u2013711, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28025","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T16:01:09Z","timestamp":1556208069000},"page":"706-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A randomized controlled trial of adjuvant mitomycin\u2010c in endoscopic surgery for laryngotracheal stenosis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-4547","authenticated-orcid":false,"given":"Katherine C.","family":"Yung","sequence":"first","affiliation":[{"name":"San Francisco Voice and Swallowing  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1538","authenticated-orcid":false,"given":"Joseph","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, San Francisco  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-2929","authenticated-orcid":false,"given":"Mark S.","family":"Courey","sequence":"additional","affiliation":[{"name":"Eugen Grabscheid Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Health System  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24410"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24963"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100412"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700201"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200417"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197903000-00016"},{"key":"e_1_2_7_9_1","first-page":"141","article-title":"Mitomycin, a new antibiotic from streptomyces","volume":"9","author":"Hata T","year":"1956","journal-title":"Int J Antibiot"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(97)00088-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32456-9"},{"key":"e_1_2_7_12_1","first-page":"610","article-title":"Studies on the pterygium. 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