{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:46:13Z","timestamp":1793277973901,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,2]]},"abstract":"\n Objective<\/jats:title>\n \n Epiglottitis is typically considered a pediatric disease; however, there is growing evidence that the incidence of adult epiglottitis has changed since the introduction of the\n Haemophilus influenzae<\/jats:italic>\n vaccine. The literature is composed of multiple small series with differing findings. To date, there has been no attempt to collaborate evidence on predictors of airway intervention in this disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The population of interest was adults with a diagnosis of epiglottitis. The primary outcome in this review was incidence of airway intervention. A comprehensive literature search was conducted of the MEDLINE and Embase databases, and a separate random\u2010effects model meta\u2010analysis was undertaken for all outcome data. Moderator tests for comparison between prevaccine and postvaccine estimates were made, and absolute risk difference (RD) and relative risk (RR) calculations were made for all predictors of airway intervention.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty studies and a total of 10,148 patients were finally included for meta\u2010analysis. A significant decrease in airway intervention was seen post vaccine introduction introduction from 18.8% to 10.9% (\n P<\/jats:italic>\n =\u20090.01). The presence of an abscess (RD 0.27,\n P<\/jats:italic>\n =\u20090.04; RR 2.45,\n P<\/jats:italic>\n \u2009<\u20090.001), stridor (RD 0.64,\n P<\/jats:italic>\n \u2009<\u20090.001; RR 7.15,\n P<\/jats:italic>\n \u2009<\u20090.001), or a history of diabetes mellitus (RD 0.11,\n P<\/jats:italic>\n =\u20090.02; RR 2.15,\n P<\/jats:italic>\n =\u20090.01) were associated with need for airway intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In the postvaccine era, clinicians should expect to have to secure airways in 10.9% of cases. The presence of an epiglottic abscess, stridor, or a history of diabetes mellitus are the most reliable clinical features associated with need for airway intervention.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n NA\n Laryngoscope<\/jats:italic>\n , 130:465\u2013473, 2020\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.28076","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:21:35Z","timestamp":1559906495000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A systematic review and meta\u2010analysis of predictors of airway intervention in adult epiglottitis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-3448","authenticated-orcid":false,"given":"Anders","family":"Sideris","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"ORL Head and Neck Research Group Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"ORL Head and Neck Research Group Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cumming","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"ORL Head and Neck Research Group Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Havas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"ORL Head and Neck Research Group Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002446"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1482"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)00106-Z"},{"key":"e_1_2_6_6_1","first-page":"80","article-title":"Review: Cook RD, Weisberg S. 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