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We assessed whether lower baseline estimated glomerular filtration rate calculated using creatinine (eGFR<jats:sub>Cr<\/jats:sub>), as well as decline in eGFR<jats:sub>Cr<\/jats:sub> over time, were associated with incident hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum creatinine was measured in 1,843 individuals aged 48 to 80 years without hearing loss at the start of the Epidemiology of Hearing Loss Study in 1993. Follow\u2010up creatinine assessments were conducted at 5 (n = 1,526) and 10 (n = 1,095) years. Hearing tests were conducted at baseline and at 5\u2010, 10\u2010, and 15\u2010year follow\u2010up visits. The risk of hearing loss was assessed as a function of baseline eGFR<jats:sub>Cr<\/jats:sub> as well as a function of a 20% decline in eGFR<jats:sub>Cr<\/jats:sub> between baseline and 5 years and between 5 and 10 years. Cox proportional hazards regression was used to examine the risk of incident speech\u2010frequency hearing loss, defined as pure tone average (PTA)\u2009&gt;\u200925 decibels hearing loss for thresholds at 0.5, 1, 2, and 4 kHz (PTA<jats:sub>0.5,1,2,4<\/jats:sub>) in either ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 15,676 person\u2010years of follow up, there were 802 cases of incident hearing loss. There was no statistically significant association between lower baseline eGFR<jats:sub>Cr<\/jats:sub> and risk of incident hearing loss. Decline in eGFR<jats:sub>Cr<\/jats:sub> was also not associated with incident hearing loss at speech frequencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, there was no significant association between eGFR<jats:sub>Cr<\/jats:sub> or decline in eGFR<jats:sub>Cr<\/jats:sub> using the serum creatinine\u2010based equation and risk of incident hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 <jats:italic>Laryngoscope<\/jats:italic>, 130:E213\u2013E219, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28088","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:03:33Z","timestamp":1559052213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic kidney disease and the risk of incident hearing loss"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2151","authenticated-orcid":false,"given":"Shruti","family":"Gupta","sequence":"first","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital  Madison Wisconsin U.S.A."},{"name":"Renal Division, Department of Medicine Brigham and Women's Hospital  Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon G.","family":"Curhan","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital  Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Cruickshanks","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences School of Medicine and Public Health, University of Wisconsin  Madison Wisconsin U.S.A."},{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin  Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.K.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin  Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin  Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Curhan","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital  Madison Wisconsin U.S.A."},{"name":"Renal Division, Department of Medicine Brigham and 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