{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:05:00Z","timestamp":1787799900452,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Epistaxis is the most common symptom in patients with hereditary hemorrhagic telangiectasia (HHT), with the greatest negative impact on quality of life (QoL). Repeated intranasal submucosal bevacizumab injections (RISBI) is a relatively new treatment option for moderate or severe grades of epistaxis in HHT. However, the effect of RISBI on QoL is not fully evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, non\u2010comparative study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients treated by RISBI for HHT\u2010associated epistaxis between June 2011 and August 2013 were prospectively invited to the present study. The end of follow\u2010up was October 2013. The patients were requested to answer QoL questionnaires before the first treatment, and 6\u20108 weeks after the last treatment. Three levels of QoL were assessed: Overall QoL using Cantril's Self\u2010Anchoring Ladder; Health\u2010related QoL using Short Form 36 (SF\u201036), and Disease\u2010specific QoL. Psychological distress was measured with the Hospital Anxiety and Depression scale (HADS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were treated with RISBI during the period referred to above. Twenty\u2010three patients completed the QoL questionnaires. The average number of treatments per patient was 2.15\u2009\u00b1\u20091.3 (Range: 1\u20135). The mean overall QoL improved from 6.47\u2009\u00b1\u20091.9 to 7.26\u2009\u00b1\u20091.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Several dimensions measured by SF\u201036 were significantly improved with a medium to strong effect size. HADS demonstrated a significant decrease in psychological distress after the last treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HHT patients treated by RISBI improved in several aspects of quality of life, and psychological distress decreased. RISBI was an effective treatment option for moderate and severe grades of HHT\u2010associated epistaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 (case series).<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 130:E284\u2013E288, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28179","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T15:18:40Z","timestamp":1562685520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intranasal bevacizumab injections improve quality of life in HHT patients"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-6043","authenticated-orcid":false,"given":"Johan","family":"Steineger","sequence":"first","affiliation":[{"name":"Division of Head and Neck and Reconstructive Surgery, Department of Otorhinolaryngology, Head and Neck Surgery Oslo University Hospital  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