{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:14:05Z","timestamp":1788678845158,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The indications for and efficacy of induction chemotherapy in the management of squamous cell carcinoma of the head and neck is controversial. With the advent of human papillomavirus (HPV)\u2013related cancers, survival has improved significantly. Here we present a group of patients with tonsil cancer treated with induction chemotherapy followed by surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients with tonsil cancer were treated with induction chemotherapy, consisting of cisplatin and docetaxel, followed by neck dissection and radical tonsillectomy. Twenty\u2010six patients were HPV+, 28 were nonsmokers or long\u2010term former smokers, and 28 were T1\/T2. Fourteen patients required postoperative chemoradiotherapy (CRT). Median follow\u2010up time was 4.1 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A complete response to induction chemotherapy was achieved in 45% (17) of patients. In total, 76% (29\/38) of patients were successfully treated: 53% (20\/38) with chemotherapy and surgery alone, and 24% (9\/38) required postoperative CRT. Almost 90% (23\/26) of HPV+ and half (6\/12) of HPV\u2212 patients are no evidence of disease (NED). HPV status is a significant prognostic factor (<jats:italic>P<\/jats:italic> =\u2009.02). Only 38% (5\/13) of current smokers were NED compared to 96% (24\/25) of nonsmokers (<jats:italic>P<\/jats:italic> =\u2009.0002). All HPV+ nonsmokers (20\/20) were NED at last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, the primary driver of prognosis was smoking status. HPV status and T stage were also important. The prognosis for HPV+ nonsmokers is extremely good; most likely regardless of treatment. Treatment failures have a poor chance of salvage, irrespective of treatment type. With the major exception of HPV\u2212 smokers, induction chemotherapy followed by surgery with selective CRT is a viable treatment option for tonsil cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 130:1206\u20131211, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28180","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T12:29:59Z","timestamp":1563452999000},"page":"1206-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Presurgical induction chemotherapy for squamous cell carcinoma of the tonsil"],"prefix":"10.1002","volume":"130","author":[{"given":"Mark S.","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Medical Oncology Erie County Medical Center  Buffalo New York"},{"name":"Department of Surgery State University of New York at Buffalo  Buffalo New York"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery State University of New York at Buffalo  Buffalo New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-7632","authenticated-orcid":false,"given":"John T.","family":"Loree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Medical Oncology Erie County Medical Center  Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurin R.","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Medical Oncology Erie County Medical Center  Buffalo New York"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery State University of New York at Buffalo  Buffalo New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Medical Oncology Erie County Medical Center  Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery State University of New York at Buffalo  Buffalo New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-4832","authenticated-orcid":false,"given":"Adam R.","family":"Szymanowski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery State University of New York at Buffalo  Buffalo New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thom R.","family":"Loree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Medical Oncology Erie County Medical Center  Buffalo New York"},{"name":"Department of Surgery State University of New York at Buffalo  Buffalo New York"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery State University of New York at Buffalo  Buffalo New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24829"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80341-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.06.032"},{"key":"e_1_2_6_5_1","unstructured":"National Comprehensive Cancer Network. 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