{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:22:36Z","timestamp":1785900156134,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether the Voice Handicap Index\u201010 (VHI\u201010) predicts diagnoses made via laryngoscopy\/stroboscopy, as compared to common clinical inquiries about vocal characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively collected data from a cohort of 204 consecutive patients newly presenting for ambulatory laryngology evaluation. Each patient completed the VHI\u201010 and 16 concurrent mainstream queries about vocal characteristics such as weakness, breathiness, fatiguability, or inability to shout. Using the objective diagnoses made by laryngoscopy\/stroboscopy as a gold standard, the area under the receiver operating characteristic curves (AUC), sensitivity, and specificity were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For unilateral vocal fold paralysis, VHI\u201010 scores had an AUC of 0.78 (95% CI, 0.68\u20130.88) and had better discrimination than 12 common clinical queries. At a threshold score of \u226511, VHI\u201010 sensitivity was 0.94; at a threshold of \u226531, specificity was 0.91. For laryngeal stenosis, the VHI\u201010 score demonstrated moderate discrimination, with an AUC of 0.79 (95% CI, 0.56\u20131.00) and higher discrimination than three common clinical queries. At a threshold score of \u226511, VHI\u201010 sensitivity was 1.00; at a threshold of \u226531, specificity was 0.89. Both VHI\u201010 scores and common clinical queries had low diagnostic ability for vocal fold paresis, laryngopharyngeal reflux (LPR), paradoxical vocal fold motion, and vocal fold scar or atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The VHI\u201010 score is an effective diagnostic indicator of laryngoscopy\/stroboscopy findings of vocal fold paralysis and laryngeal stenosis, performing better than multiple mainstream queries about vocal characteristics. VHI\u201010 scores and common clinical queries are limited in their ability to indicate paresis, reflux, paradoxical motion, and vocal fold scar or atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2c <jats:italic>Laryngoscope<\/jats:italic>, 130:992\u2013999, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28207","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T13:42:25Z","timestamp":1565962945000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is a voice\u2010specific instrument more indicative of stroboscopy results than common clinical queries?"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-9238","authenticated-orcid":false,"given":"Elliana Kirsh","family":"DeVore","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard 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