{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:18:09Z","timestamp":1762543089514,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thyroid lobectomy is recommended with total laryngectomy in the National Comprehensive Cancer Network guidelines. However, it is associated with a 32% to 89% risk of hypothyroidism, which is a problem for patients without access to thyroid hormone monitoring and replacement. A number of studies have reported a low incidence of thyroid gland involvement and recommended preserving the thyroid gland in favorable cases. Yet there are no studies that report whether thyroid preserving laryngectomy for laryngeal cancer adversely affects oncologic outcomes compared to patients who have undergone thyroid lobectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether patients who underwent thyroid gland preserving laryngectomy had higher local recurrence rates or poorer disease\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective folder review of patients who underwent a total laryngectomy over a 12\u2010year period was conducted. Local recurrence and disease\u2010free survival were determined for patients who had both their thyroid lobes preserved and compared with those who had a thyroid lobectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients had thyroid preserving laryngectomy and 73 patients had a thyroid lobectomy. The duration of follow\u2010up was 18 to 132 months (median, 30; IQR, 30). There was no significant difference in local recurrence rates (<jats:italic>P<\/jats:italic> = .76) or survival curves between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thyroid preserving laryngectomy in selected patients with advanced laryngeal carcinoma does not increase local recurrence rates, nor does it negatively affect disease\u2010free survival. Thyroid preservation is appropriate when intraoperative inspection of the larynx shows no extralaryngeal extension or when paratracheal nodal metastases are not a concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 4 <jats:bold><jats:italic>Laryngoscope, 130:1465\u20131469, 2020<\/jats:italic><\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28235","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T13:53:39Z","timestamp":1565272419000},"page":"1465-1469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Does Thyroid Gland Preserving Total Laryngectomy Affect Oncological Control in Laryngeal Carcinoma?"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-8959","authenticated-orcid":false,"given":"Jessica K.","family":"McGuire","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-6379","authenticated-orcid":false,"given":"Gerrit","family":"Viljoen","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Rocke","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Dalvie","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes J.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Faculty of Health Sciences, University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195510000-00001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890040105"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90145-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.10.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25263"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.10.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9376-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.10.031"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199109000-00003"},{"key":"e_1_2_6_11_1","unstructured":"The Committee Members. 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