{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:29:00Z","timestamp":1791916140504,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008894","name":"Stryker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008894","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy and safety of cryoablation of the posterior nasal nerve (PNN) for treatment of chronic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective single\u2010arm trial of 98 adult patients at six U.S. centers with chronic allergic and nonallergic rhinitis. PNN cryoablation was performed in\u2010office under local anesthesia using a handheld device. Patients discontinued use of intranasal ipratropium 3\u2009days prior to treatment and throughout the study period. Reflective Total Nasal Symptom Score (rTNSS) was measured at pretreatment baseline and posttreatment at 1 month, 3 months, 6 months, and 9 months. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was completed at pretreatment and 3 months posttreatment. Adverse effects and postprocedure medication usage were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010eight procedures (100%) were successfully completed. rTNSS significantly improved over pretreatment baseline (6.1\u2009\u00b1\u20091.9) at 1 month (2.9\u2009\u00b1\u20091.9, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), 3 months (3.0\u2009\u00b1\u20092.3, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), 6 months (3.0\u2009\u00b1\u20092.1, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and 9 months (3.0\u2009\u00b1\u20092.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) postprocedure. Nasal congestion and rhinorrhea subscores improved significantly at all time points (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Both allergic and nonallergic rhinitis subcohorts showed improvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), with a comparable degree of improvement between groups. RQLQ significantly improved over pretreatment baseline (3.0\u2009\u00b1\u20091.0) at 3 months (1.5\u2009\u00b1\u20091.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and all RQLQ subdomains demonstrated improvement. Of 54 patients using intranasal medication at baseline, 19 (35.2%) were able to discontinue use. Twenty\u2010nine adverse effects were reported, including headache, epistaxis, and sinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryoablation of the PNN for chronic rhinitis is safe and can result in relief of nasal symptoms and improvements in quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p><jats:bold>4 <jats:italic>Laryngoscope<\/jats:italic>, 130: 1877\u20131884, 2020<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28301","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:44:21Z","timestamp":1569905061000},"page":"1877-1884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Cryosurgical ablation for treatment of rhinitis: A prospective multicenter study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-5880","authenticated-orcid":false,"given":"Michael T.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunhee","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford California U.S.A."},{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Daegu Veterans Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"23","article-title":"Epidemiology of rhinitis: allergic and nonallergic","volume":"19","author":"Settipane RA","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X41408"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100057716"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-9733.2009.01145.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"},{"key":"e_1_2_7_7_1","unstructured":"US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Allergic rhinitis: developing drug products for treatment. Guidance for industry 2018. Available at:https:\/\/www.fda.gov\/downloads\/drugs\/guidances\/ucm071293.pdf. Accessed August 26 2019."},{"key":"e_1_2_7_8_1","unstructured":"US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Nonallergic rhinitis: developing drug products for treatment. Guidance for industry 2018. Available at:https:\/\/www.fda.gov\/ucm\/groups\/fdagov\u2010public\/@fdagov\u2010drugs\u2010gen\/documents\/document\/ucm486105.pdf. Accessed August 26 2019."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70380-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283630cd8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236628"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418800879"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100158281"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.01.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197304000-00007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132884"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065894781874313"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000216"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4141"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480801935525"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.284"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.11.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.01.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.11.006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116008008"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:18:39Z","timestamp":1693862319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/lary.28301"],"URL":"https:\/\/doi.org\/10.1002\/lary.28301","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}