{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:27:19Z","timestamp":1793384839030,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>22q11.2\u2010deletion syndrome is a genetic condition that affects 1:3000 births. In addition to cardiac anomalies and immunosuppression, individuals with 22q11.2\u2010deletion syndrome can have feeding difficulties from birth resulting in failure to thrive and infections. This study aims to characterize the dysphagia seen in infants with 22q11.2\u2010deletion syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective chart review of infants with 22q11.2\u2010deletion syndrome who underwent videofluoroscopic swallow studies (VFSS) from June 1, 2008 to January 1, 2018 at a tertiary children's hospital. Demographic data and VFSS findings were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients were identified, 52% were females, and mean age at VFSS was 71\u2009days. In their lifetime, 30% of the patients had at least 1 episode of pneumonia, 66% had NG\u2010tube placement and 41% required G\u2010tube placement. 93% had oral\u2010phase dysphagia, and 89% had pharyngeal\u2010phase dysphagia. Twenty\u2010two patients (50%) demonstrated evidence of penetration. Eighteen patients (41%) showed tracheal aspiration. Of the patients that showed tracheal aspiration, 83% of them aspirated \u201csilently.\u201d Three patients (7%) had upper esophageal sphincter (UES) opening dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vast majority of the infants with 22q11.2\u2010deletion syndrome referred for swallow studies demonstrated evidence of dysphagia in both oral and pharyngeal phases with deficits in swallow physiology not yet documented in other studies. Importantly, more than 80% of these infants showed evidence of \u201csilent\u201d tracheal aspiration, which can lead to recurrent pneumonia and significant morbidity if overlooked. Prompt recognition is paramount in these infants to intervene early and reduce long\u2010term complications and also develop targeted interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 130:2532\u20132536, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28317","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:54:04Z","timestamp":1570798444000},"page":"2532-2536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Patterns of Dysphagia and Airway Protection in Infants with 22q11.2\u2010Deletion Syndrome"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-8496","authenticated-orcid":false,"given":"Nicole S.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Baylor College of Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Rappazzo","sequence":"additional","affiliation":[{"name":"Department of Speech Language and Learning Texas Children's Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Speech Language and Learning Texas Children's Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Speech Language and Learning Texas Children's Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julina","family":"Ongkasuwan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Baylor College of Medicine  Houston Texas U.S.A."},{"name":"Pediatric Otolaryngology Texas Children's Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000900009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21576"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.08.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.09.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105356"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"BaByVFSSImP\u00a9 a novel measurement tool for videofluoroscopic assessment of swallowing impairment in bottle\u2010fed babies: establishing a standard","author":"Martin\u2010Harris 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