{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:44:22Z","timestamp":1780548262703,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the natural history of vocal fold cysts, by undertaking a retrospective analysis of data from a single clinical institute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients diagnosed with vocal fold cysts were identified from January 2006 to June 2018. A total of 87 patients that elected not to have surgery or who had an interval of observation greater than 90\u2009days prior to surgical intervention were further analyzed. The primary outcome was whether the cyst enlarged, reduced in size, resolved or ruptured. The secondary outcome measures were whether cyst characteristics (translucent or opaque by gross appearance and\/or the presence of inflammation), voice therapy or duration of follow up (\u2264\/&gt;\u2009300\u2009days) had an impact upon natural history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 65 females and 22 males (47\u2009years\u2009\u00b117). The mean duration of follow up was 589\u2009days (Range 21 \u2013 4523\u2009days). The majority of cysts did not change (70.11%). The rest enlarged (12.64%), reduced in size (13.79%), resolved (1.15%) or ruptured (1.15%). There was no statistically significant relationship between the presence or absence of clinical signs of inflammation (<jats:italic>P\u2009=<\/jats:italic> .633) or voice therapy (<jats:italic>P\u2009=<\/jats:italic> .785) on natural history. There was an equivocal relationship between gross cyst appearance and natural history (<jats:italic>P\u2009=<\/jats:italic> .054), however there was a statistically significant relationship between the duration of follow up (<jats:italic>P\u2009=<\/jats:italic> .006) and natural history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most vocal fold cysts appear to remain static in size over time. About 30% change, with half of these enlarging and half shrinking. In addition to some possibility of change in size, there is a small chance of resolution or spontaneous rupture with potentially serious consequences to the voice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 130:2202\u20132207, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28377","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T16:30:24Z","timestamp":1573576224000},"page":"2202-2207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Natural History of Vocal Fold Cysts"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-3875","authenticated-orcid":false,"given":"Diana N.","family":"Kirke","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-2073","authenticated-orcid":false,"given":"Lucian","family":"Sulica","sequence":"additional","affiliation":[{"name":"Sean Parker Institute for the Voice, Department of Otolaryngology\u2013Head and Neck Surgery Weill Cornell Medical College  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.06.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.06.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199205000-00017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80039-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200205"},{"issue":"9","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1288\/00005537-198509000-00014","article-title":"Epidermoid cysts, sulci, and mucosal bridges of the true vocal cord: a report of 157 cases","volume":"95","author":"Bouchayer M","year":"1985","journal-title":"Laryngoscope"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22421"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.12.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1315-y"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:21:52Z","timestamp":1693902112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/lary.28377"],"URL":"https:\/\/doi.org\/10.1002\/lary.28377","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"2019-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}