{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:17:18Z","timestamp":1782364638740,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Indication for postoperative radiotherapy in patients with locally circumscribed tumors (pT1\u2013pT2) and a single ipsilateral lymph node metastasis (pN1) is debatable. The aim of this study was to evaluate the oncological long\u2010term outcome of patients with pT1\u2010pT2 pN1 squamous cell carcinoma (SCC) of the oral cavity, the oropharynx, and the hypopharynx without extracapsular spread (ECS) after a margin\u2010negative surgical resection, who either received or did not receive postoperative (chemo)radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The oncological outcome of patients with pT1\u2010pT2 pN1 SCC without ECS was evaluated retrospectively. All patients underwent primary tumor resection that included transoral laser microsurgery and neck dissection at an academic tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 65 identified patients treated between 1986 and 2015 (18 oral cavity, 30 oropharynx, 17 hypopharynx), 21 (32%) received postoperative radiotherapy, and 44 (68%) were treated by surgery alone. The group of patients receiving postoperative treatment showed a significantly superior 5\u2010year disease\u2010specific (94.4% vs. 73.2%, <jats:italic>P<\/jats:italic> =\u2009.029) and recurrence\u2010free survival (85.2% vs. 43.2%, <jats:italic>P<\/jats:italic> =\u2009.002), as well as a higher local control rate (90.2% vs. 64.9%, <jats:italic>P<\/jats:italic> =\u2009.042). The overall survival was 71.4% vs. 62.6% (<jats:italic>P<\/jats:italic> =\u2009.53). The mean follow\u2010up was 80.7 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with locally circumscribed carcinomas and a single ipsilateral ECS\u2010negative lymph node metastasis seem to benefit from postoperative radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 130:E530\u2013E538, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28394","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T11:36:36Z","timestamp":1576323396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-0149","authenticated-orcid":false,"given":"Bernhard G.","family":"Weiss","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital, Ludwig Maximilian University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalia Z.","family":"Anczykowski","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Flach","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital, Ludwig Maximilian University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital, Ludwig Maximilian University Munich  Munich 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Ludwig Maximilian University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Ihler","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital, Ludwig Maximilian University Munich  Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders University Hospital, Ludwig Maximilian University Munich  Munich 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