{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:52Z","timestamp":1788829432721,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The anterior commissure is considered a laryngeal subsite, but it is not taken into account in the current T\u2010staging system. The impact of anterior commissure involvement (ACI) on the oncologic outcomes of T1 glottic tumors has not been well defined and remains controversial. The aim of this study was to assess the influence of ACI in the prognosis of T1 glottic tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis of observational studies was performed by including studies published up to July 2019. Studies were selected if they had investigated the local control rate (LCR) at 5\u2009years of clinical stage I (T1 and N0) glottic squamous cell carcinoma with and without ACI. The difference in LCR at 5\u2009years between T1 glottic tumors without and with ACI was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis showed that the difference in LCR at 5\u2009years between T1 glottic tumors without and with ACI is 12% (95% confidence interval: 8%\u201016%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090,0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u200934.81%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study pointed out that the anterior commissure involvement is a negative prognostic factor in LCR at 5\u2009years for T1 glottic tumors. Our results suggest the need to consider ACI in the T staging of glottic tumors. <jats:bold><jats:italic>Laryngoscope<\/jats:italic>, 130:1932\u20131940, 2020<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28395","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T14:13:30Z","timestamp":1573654410000},"page":"1932-1940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1958-7177","authenticated-orcid":false,"given":"Michele","family":"Tulli","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Scientific Institutes of Hospitalization and Care San Raffaele Hospital, Vita\u2010Salute University  Milan 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