{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:07:29Z","timestamp":1792624049682,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The role of traditional nuclear medicine studies in the management of malignant otitis externa (MOE) is unclear and there are ongoing debates regarding their diagnostic value. The authors perform a systematic review and meta\u2010analysis to assess the sensitivity and specificity of traditional nuclear medicine studies in the diagnosis of MOE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In accordance with PRISMA guidelines, a query of the Medline, Embase, Web of Science, and Cochrane databases was undertaken. The primary outcomes of interest were the sensitivity and specificity of traditional nuclear medicine studies to detect MOE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the initial 1317 hits from the four databases, 20 articles with a combined 608 patients were ultimately included in the review. The pooled sensitivities for Technetium\u201099 and Gallium\u201067 were 85.1% (95% CI, 72.0\u201398.1%) and 71.2% (95% CI, 55.1\u201387.3%) respectively. The available evidence suggested poor specificity of these modalities, but was insufficient for meta\u2010analysis. Neither modality was shown to be effective in the assessment of disease resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sensitivities of Technetium\u201099 and Gallium\u201067 to detect MOE are less favorable than was initially thought. Given this finding and their poor specificity, lack of anatomic resolution, unproven ability to detect disease resolution and variable availability, this review does not support the routine use of these studies in the management of MOE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 130:1812\u20131816, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28411","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T14:14:50Z","timestamp":1574345690000},"page":"1812-1816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Meta\u2010analysis does not support routine traditional nuclear medicine studies for malignant otitis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-9296","authenticated-orcid":false,"given":"Wiliam James","family":"Moss","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2010Head &amp; Neck Surgery, Department of Surgery Commonwealth Health Center  Saipan CNMI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Finegersh","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery, Department of Surgery University of California, San Diego  San Diego California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Texas Southwestern  Dallas Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-4637","authenticated-orcid":false,"given":"Jason Ying Kuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery The Chinese University of Hong Kong  Shatin HK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196808000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000518"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198106000-00014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.149.3.6580674"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198308000-00004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100101562"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001812"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1295468"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814528301"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_6_13_1","unstructured":"How to cite the Levels of Evidence Table OCEBM Levels of Evidence Working Group. \u201cThe Oxford 2011 Levels of Evidence\u201d. 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