{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:15:01Z","timestamp":1790903701415,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the correlation of sinonasal symptoms and quality of life with size and position of nasal septal perforation (NSP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a prospective observational study in a tertiary referral center involving adult patients presented with NSP. The Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022) and its clinico\u2010psychometric domains were analyzed, including additional NSP\u2010specific symptoms (nasal crusting, epistaxis, and whistling noise during nasal breathing). The size of NSP was measured radiologically by calculating the area in cm<jats:sup>2<\/jats:sup> and anteroposterior (AP) diameter. Position of perforation was determined clinically by distance from columella to the anterior edge of the perforation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were included in this study (22 males). The most common etiology of NSP was iatrogenic. The mean SNOT\u201022 score was 50.8 (standard deviation 23.8), and mean NSP size was 3.0 cm<jats:sup>2<\/jats:sup>. No statistical correlation was observed between the total SNOT\u201022 score with either position or size of NSP. As for NSP\u2010specific symptoms, there was a statistically significant negative correlation with the size of perforation (A\u2010P diameter) (r = \u22120.34, <jats:italic>P<\/jats:italic> = 0.03) and position of the perforation (r = \u22120.49, <jats:italic>P<\/jats:italic> = 0.0016), suggesting that these symptoms improved with posterior and larger perforations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reported SNOT\u201022 scores were comparable to patients with recalcitrant chronic rhinosinusitis, although the scores did not correlate with size and position of NSP. Sinonasal symptoms typically observed in NSP improved with more posteriorly placed and larger sized perforations. This study provides an insight into the quality\u2010of\u2010life impact of NSP and affirms the clinical observation that anterior NSP are more symptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><jats:p><jats:italic>Laryngoscope<\/jats:italic>, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28415","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T15:45:53Z","timestamp":1574869553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Correlation of sinonasal symptoms with the size and position of nasal septal perforations"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-1637","authenticated-orcid":false,"given":"Grace C.","family":"Khong","sequence":"first","affiliation":[{"name":"Liverpool Head and Neck Centre, Aintree University Hospital NHS Foundation Trust  Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7213-0387","authenticated-orcid":false,"given":"Samuel C.","family":"Leong","sequence":"additional","affiliation":[{"name":"Liverpool Head and Neck Centre, Aintree University Hospital NHS Foundation Trust  Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0690-0"},{"key":"e_1_2_6_3_1","first-page":"102","article-title":"Surgical treatment of nasal septal perforations: our experience","volume":"26","author":"Re M","year":"2006","journal-title":"Acta Otothinolaryngol Ital"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.9.5.321"},{"key":"e_1_2_6_5_1","first-page":"10","article-title":"Patient reported outcome measures in rhinology","volume":"47","author":"Hopkins 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