{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:47:56Z","timestamp":1775857676268,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Studies have demonstrated improvement in Eustachian tube dysfunction (ETD) symptomatology after functional endoscopic sinus surgery (FESS); however, factors associated with ETD symptom alteration have not been elucidated. This study evaluated factors associated with improvement and normalization of ETD symptoms after FESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was performed of FESS patients who had clinically significant ETD symptoms based on the Eustachian Tube Dysfunction Questionnaire\u20107 (ETDQ\u20107\u2009\u2265\u20092.1) without middle ear effusion (MEE) preoperatively. Study patients were identified as those with a normalized ETDQ\u20107 at 2 months postoperatively. Controls were patients whose ETDQ\u20107 did not normalize at 2 months. Demographics, surgery characteristics, chronic rhinosinusitis phenotype, Lund\u2010Mackay score, temporomandibular joint dysfunction (TMJD), preoperative ETDQ\u20107 and SNOT\u201022 scores, and tympanograms were analyzed. Univariate and multivariate analyses were performed comparing study cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected on 165 patients, with 46% patients having clinically significant preoperative ETD and 60 patients meeting final study inclusion\/exclusion criteria. FESS was associated with both SNOT\u201022 and ETDQ\u20107 improvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Nasal polyposis was associated with a higher probability of ETDQ\u20107 normalization (OR 4.429, <jats:italic>P<\/jats:italic> = 0.035). Factors associated with failure of ETDQ\u20107 normalization included TMJD (OR 0.086, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, 95% CI 0.019\u20130.391) and high preoperative ETDQ\u20107 (OR 0.140, <jats:italic>P<\/jats:italic> = 0.006, 95% CI 0.032\u20130.613).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with clinically significant ETD symptoms without MEE, FESS was associated with ETDQ\u20107 improvement. Nasal polyposis was associated with an increased probability of normalization of ETD symptoms postoperatively, whereas TMJD had a negative association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b <jats:italic>Laryngoscope<\/jats:italic>, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28416","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T16:58:46Z","timestamp":1574269126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Predictors of eustachian tube dysfunction improvement and normalization after endoscopic sinus surgery"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-6386","authenticated-orcid":false,"given":"Thomas S.","family":"Higgins","sequence":"first","affiliation":[{"name":"Rhinology, Sinus &amp; Skull Base, Kentuckiana Ear, Nose &amp; Throat  Louisville Kentucky U.S.A."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Louisville  Louisville Kentucky U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-8676","authenticated-orcid":false,"given":"Zachary J.","family":"Cappello","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Louisville  Louisville Kentucky U.S.A."},{"name":"Section of Rhinology, Sinus and Skull Base Surgery, Head &amp; Neck Institute, Cleveland Clinic Foundation  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-6355","authenticated-orcid":false,"given":"Arthur W.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery, Cedars Sinai Medical Center  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Y.","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Indiana University School of Medicine  Indianapolis Indiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Sindwani","sequence":"additional","affiliation":[{"name":"Section of Rhinology, Sinus and Skull Base Surgery, Head &amp; Neck Institute, Cleveland Clinic Foundation  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900214"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22056"},{"key":"e_1_2_7_4_1","volume-title":"Eustachian tube dysfunction","author":"Poe D","year":"2017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.07.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816683342"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23223"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26827"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1045"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22028"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2016.2086"},{"issue":"57","key":"e_1_2_7_13_1","first-page":"73","article-title":"Eustachian tube dysfunction in chronic rhinosinusitis: pre\u2010 and post\u2010operative results following endoscopic sinus surgery, a prospective study","volume":"1","author":"Bowles PFD","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181edb703"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116009300"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464441"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147279"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950181387"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12475"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:53:01Z","timestamp":1693540381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/lary.28416"],"URL":"https:\/\/doi.org\/10.1002\/lary.28416","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}